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236470

Sigma-Aldrich

Chromium(VI) oxide

ACS reagent, ≥98.0%

Synonym(s):

Chromic anhydride

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About This Item

Empirical Formula (Hill Notation):
CrO3
CAS Number:
1333-82-0
Molecular Weight:
99.99
EC Number:
215-607-8
MDL number:
MFCD00010952
UNSPSC Code:
12352303
PubChem Substance ID:
329752434
NACRES:
NB.24

grade

ACS reagent

Quality Level

200

Assay

≥98.0%

form

powder or crystals

reaction suitability

reagent type: oxidant

impurities

≤0.01% insolubles

pH

<1 (20 °C, 100 g/L)

mp

196 °C (dec.) (lit.)

anion traces

chloride (Cl-): ≤0.005%
nitrate (NO3-): ≤0.05%
sulfate (SO42-): ≤0.005%

cation traces

Fe, Al, Ba: ≤0.03%
Na: ≤0.2%

SMILES string

O=[Cr](=O)=O

InChI

1S/Cr.3O

InChI key

WGLPBDUCMAPZCE-UHFFFAOYSA-N

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General description

Chromium(VI) oxide is an oxidizing reagent for the oxidation of carbon-hydrogen bonds to alcohols, alkylaromatics to ketones and carboxylic acids, alkenes to α, β-unsaturated ketones, arenes to quinones, and alcohols to aldehydes, ketones, acids, and keto acids.

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Muta. 1B - Ox. Sol. 1 - Repr. 2 - Resp. Sens. 1 - Skin Corr. 1A - Skin Sens. 1 - STOT RE 1 Inhalation - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

5.1A - Strongly oxidizing hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Chromium (VI) Oxide
Freeman F, et al.
e-EROS Encyclopedia of Reagents for Organic Synthesis (2001)
Chromium (VI) Oxide.
Freeman F, et al.
e-EROS Encyclopedia of Reagents for Organic Synthesis. (2008)
Chromium (VI) oxide-catalyzed oxidation of arenes with periodic acid.
Yamazaki S.
Tetrahedron Letters, 42(19), 3355-3357 (2001)
Seongmin Lee et al.
Organic letters, 11(1), 5-8 (2008-12-06)
The C14,15-dihydro-C22,25-epi north unit of cephalostatin 1 has been synthesized in 11 operations from commercially available hecogenin acetate via multiple reductions and oxidations. The key transformations include (i) Cr(VI)-catalyzed E-ring opening, (ii) C17 hydroxylation, and (iii) a base-triggered cyclization cascade.
Adam Szelag et al.
Polish journal of pharmacology, 55(6), 1097-1103 (2004-01-20)
Hexavalent chromium compounds exhibit higher toxicity than its trivalent compounds since chromium ions in the +6 oxidation state easily cross biological membranes. It has recently been proposed that substances reducing chromium ions from the +6 to the less toxic +3
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