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PHR1326

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Calcium carbonate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Calcium carbonate

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About This Item

Linear Formula:
CaCO3
CAS Number:
Molecular Weight:
100.09
Beilstein:
8008338
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to USP 1086403

API family

calcium carbonate

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

density

2.93 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

[Ca++].[O-]C([O-])=O

InChI

1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2

InChI key

VTYYLEPIZMXCLO-UHFFFAOYSA-L

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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Calcium carbonate is a material that is widely found in nature, and is commonly referred to as calcite. Calcium carbonate is used in such processes as the manufacture of paper, paints, glass, and ceramics, the compounding of polymers, environmental applications such as wastewater treatment, and as an extender in paints and coatings.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3446 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Storage Class Code

13 - Non Combustible Solids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Polysaccharides and proteoglycans in calcium carbonate-based biomineralization.
José L Arias et al.
Chemical reviews, 108(11), 4475-4482 (2008-07-26)
Ling Li et al.
Nature materials, 13(5), 501-507 (2014-04-01)
Hierarchical composite materials design in biological exoskeletons achieves penetration resistance through a variety of energy-dissipating mechanisms while simultaneously balancing the need for damage localization to avoid compromising the mechanical integrity of the entire structure and to maintain multi-hit capability. Here
Ruqian Qin et al.
PloS one, 9(7), e103477-e103477 (2014-07-30)
Trees in the genus Populus and their interspecific hybrids are used across North America for fiber production and as a potential source of biofuel. Plantations of these species are severely impacted by a fungal pathogen, Sphaerulina musiva, the cause of
Claudia Gagnon et al.
PloS one, 9(10), e109607-e109607 (2014-10-10)
To examine whether combined vitamin D and calcium supplementation improves insulin sensitivity, insulin secretion, β-cell function, inflammation and metabolic markers. 6-month randomized, placebo-controlled trial. Ninety-five adults with serum 25-hydroxyvitamin D [25(OH)D] ≤55 nmol/L at risk of type 2 diabetes (with
Julyan H E Cartwright et al.
Angewandte Chemie (International ed. in English), 51(48), 11960-11970 (2012-11-06)
Although the polymorphism of calcium carbonate is well known, and its polymorphs--calcite, aragonite, and vaterite--have been highly studied in the context of biomineralization, polyamorphism is a much more recently discovered phenomenon, and the existence of more than one amorphous phase

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