MABE167
Anti-SNAI1 Antibody, clone 10H4.1
clone 10H4.1, from mouse
Synonym(s):
Zinc finger protein SNAI1, Protein snail homolog 1, Protein sna
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All Photos(3)
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
10H4.1, monoclonal
species reactivity
human, rat, mouse
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgMκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... SNAI1(6615)
General description
SNAI1, also known as Snail homolog 1, is a transcription factor that down regulates the expression of ectodermal genes within the mesoderm and is thought to be essential for mesoderm formation in the developing embryo. SNAI1 is expressed in the kidney and in mesenchymal and epithelial cell lines. Mutations in SNAI1 have been associated with tumors.
Immunogen
Epitope: N-terminus
KLH-conjugated linear peptide corresponding to the N-terminus of Human SNAIL1.
Application
Anti-SNAI1 Antibody, clone 10H4.1 is a highly specific mouse monoclonal antibody, that targets Zinc Finger Protein & has been tested in western blotting & IHC.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Western Blotting Analysis: 0.5 µg/mL from a representative lot detected SNAIL1 in 10 µg of human and mouse kidney tissue lysate.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected SNAIL1 in human kidney section and human tonsil section tissues.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected SNAIL1 in human kidney section and human tonsil section tissues.
Quality
Evaluated by Western Blotting in rat kidney tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected SNAIL1 in 10 µg of rat kidney tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected SNAIL1 in 10 µg of rat kidney tissue lysate.
Target description
~29 kDa observed
Physical form
Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
Pricing
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Li-Ting Wang et al.
EMBO reports, 21(2), e48795-e48795 (2020-01-08)
Epigenetic regulation is important for cancer progression; however, the underlying mechanisms, particularly those involving protein acetylation, remain to be fully understood. Here, we show that p300/CBP-associated factor (PCAF)-dependent acetylation of the transcription factor intestine-specific homeobox (ISX) regulates epithelial-mesenchymal transition (EMT)
Menggui Huang et al.
Nature cardiovascular research, 1(4), 372-388 (2022-05-17)
Myocardial infarction (MI) is a leading cause of death worldwide, largely because efficient interventions to restore cardiac function after MI are currently lacking. Here, we characterize vascular aberrancies induced by MI, and propose to target acquired endothelial cell (EC) changes
Jia-Xing Sun et al.
Angiogenesis, 21(3), 635-652 (2018-04-21)
Ocular neovascularization is a comprehensive process involved in retinal vascular development and several blinding diseases such as age-related macular degeneration and retinopathy of prematurity, with vascular endothelial growth factor (VEGF) regarded as the master regulator. However, the qualified effect of
Jeong Ae Park et al.
PLoS genetics, 11(7), e1005324-e1005324 (2015-07-07)
Vascular branching morphogenesis is activated and maintained by several signaling pathways. Among them, vascular endothelial growth factor receptor 2 (VEGFR2) signaling is largely presented in arteries, and VEGFR3 signaling is in veins and capillaries. Recent reports have documented that Snail
Hemin-Induced Endothelial Dysfunction and Endothelial to Mesenchymal Transition in the Pathogenesis of Pulmonary Hypertension Due to Chronic Hemolysis.
Gonzales, et al.
International Journal of Molecular Sciences, 23 (2023)
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