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Key Documents

AB5087

Sigma-Aldrich

Anti-Melanocyte Stimulating Hormone α Antibody

serum, Chemicon®

Synonym(s):

alpha-MSH, POMC, Pro-opiomelanocortin, Corticotropin-lipotropin precursor

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

sheep

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity (predicted by homology)

mammals

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
radioimmunoassay: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... POMC(5443)

Specificity

Specific for alpha-melanocyte stimulating hormone (aMSH), C-terminal.

Immunogen

MSH conjugated with bovine thyroglobulin.

Application

Anti-Melanocyte Stimulating Hormone Antibody, α detects level of Melanocyte Stimulating Hormone & has been published & validated for use in IH, RIA.
Immunohistochemistry: 1:10,000-1:50,000 on 4% paraformaldehyde fixed tissue.

RIA: 1:250,000-1:300,000.

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
CNS Control of Metabolism

Hormones & Receptors

Physical form

Sheep Serum. Liquid. Contains no preservative.
Unpurified

Storage and Stability

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

Control
Hypothalamus

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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B E Grayson et al.
Endocrinology, 151(4), 1622-1632 (2010-02-24)
The hypothalamic melanocortin system, which controls appetite and energy expenditure, develops during the third trimester in primates. Thus, maternal nutrition and health may have a profound influence on the development of this system. To study the effects of chronic maternal
Amanda H Mortensen et al.
Human molecular genetics, 24(4), 939-953 (2014-10-16)
OTX2 is a homeodomain transcription factor that is necessary for normal head development in mouse and man. Heterozygosity for loss-of-function alleles causes an incompletely penetrant, haploinsufficiency disorder. Affected individuals exhibit a spectrum of features that range from developmental defects in
Gavin A Bewick et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 19(12), 1680-1682 (2005-08-16)
Agouti-related protein (AgRP) and neuropeptide Y (NPY) are colocalized in arcuate nucleus (arcuate) neurons implicated in the regulation of energy balance. Both AgRP and NPY stimulate food intake when administered into the third ventricle and are up-regulated in states of
Angela M Ramos-Lobo et al.
eLife, 8 (2019-01-30)
Leptin regulates energy balance and also exhibits neurotrophic effects during critical developmental periods. However, the actual role of leptin during development is not yet fully understood. To uncover the importance of leptin in early life, the present study restored leptin
Sara Ramírez et al.
Cell metabolism, 25(6), 1390-1399 (2017-06-08)
Proopiomelanocortin (POMC) neurons are critical sensors of nutrient availability implicated in energy balance and glucose metabolism control. However, the precise mechanisms underlying nutrient sensing in POMC neurons remain incompletely understood. We show that mitochondrial dynamics mediated by Mitofusin 1 (MFN1)

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