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Key Documents

D-055

Supelco

N-Desethylamiodarone hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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100 G
MXP 1,486.00
500 G
MXP 4,676.00

MXP 1,486.00


Availability

Estimated to ship on23 February 2025


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100 G
MXP 1,486.00
500 G
MXP 4,676.00

About This Item

Empirical Formula (Hill Notation):
C23H26ClI2NO3
CAS Number:
Molecular Weight:
653.72
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

MXP 1,486.00


Availability

Estimated to ship on23 February 2025


To order products, please contact your local dealer.

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

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D-056A-083A-060
format

single component solution

format

single component solution

format

single component solution

format

single component solution

form

liquid

form

liquid

form

liquid

form

liquid

grade

certified reference material

grade

certified reference material

grade

certified reference material

grade

certified reference material

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

packaging

ampule of 1 mL

packaging

ampule of 1 mL

packaging

ampule of 1 mL

packaging

ampule of 1 mL

General description

A Certified Spiking Solution® for use in therapeutic drug monitoring analyses by HPLC or LCMS. N-Desethylamiodarone is the primary, active metabolite of amiodarone, an antiarrhythmic agent marketed as Pacerone®, Cordarone®, Aratac, and Atlansil and monitored by clinical labs to ensure patients remain within the drugs therapeutic range.

Application


  • Impact on Amiodarone Absorption: A study examining the effects of probiotics on drug pharmacokinetics demonstrated that E. coli Nissle 1917 alters the absorption of amiodarone in rats, which suggests implications for N-Desethylamiodarone hydrochloride, a metabolite of amiodarone, in similar biochemical studies. This provides valuable insights for research into the metabolic pathways and interactions of amiodarone derivatives (Matuskova et al., 2014).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Cordarone is a registered trademark of Sanofi S.A.
Pacerone is a registered trademark of Upsher-Smith Laboratories, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup


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    Melissa K Passarelli et al.
    Analytical chemistry, 87(13), 6696-6702 (2015-05-30)
    Detecting metabolites and parent compound within a cell type is now a priority for pharmaceutical development. In this context, three-dimensional secondary ion mass spectrometry (SIMS) imaging was used to investigate the cellular uptake of the antiarrhythmic agent amiodarone, a phospholipidosis-inducing

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