Y1396

YFLLRNP trifluoroacetate

≥98%

• Synonym(s): L-Tyrosyl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl-L-asparaginyl-L-Proline, Tyr-Phe-Leu-Leu-Arg-Asn-Pro, YFLLRNP-OH
• Empirical Formula (Hill Notation): C₄₅H₆₇N₁₁O₁₀ · xC₂HF₃O₂
• Molecular Weight: 922.08 (free base basis)
• MDL number: MFCD16879019
• UNSPSC Code: 51111800
• PubChem Substance ID: 329831587
• NACRES: NA.32

Properties

• Quality Level: 100
• Assay: ≥98%
• form: solid
• solubility: deionized water: 1 mg/mL
• storage temp.: −20°C
• SMILES string: OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N3CCC[C@H]3C(O)=O
• InChI: 1S/C45H67N11O10.C2HF3O2/c1-25(2)20-32(40(61)51-31(12-8-18-50-45(48)49)39(60)55-35(24-37(47)58)43(64)56-19-9-13-36(56)44(65)66)53-41(62)33(21-26(3)4)54-42(63)34(23-27-10-6-5-7-11-27)52-38(59)30(46)22-28-14-16-29(57)17-15-28;3-2(4,5)1(6)7/h5-7,10-11,14-17,25-26,30-36,57H,8-9,12-13,18-24,46H2,1-4H3,(H2,47,58)(H,51,61)(H,52,59)(H,53,62)(H,54,63)(H,55,60)(H,65,66)(H4,48,49,50);(H,6,7)/t30-,31-,32-,33-,34-,35-,36-;/m0./s1
• InChI key: HMDRRCMAXMJXKF-WDYYMHPRSA-N

Description

Application

YFLLRNP trifluoroacetate may be used as a powerful tool for differentiating the numerous possible activation states of the platelet thrombin receptor.

Biochem/physiol Actions

YFLLRNP is a Galpha12/13-stimulating peptide that activates the alpha granule secretion due to costimulation with either ADP or serotonin/epinephrine.[1]

YFLLRNP is a PAR-1-specific partial agonist.

YFLLRNP is a PAR-1-specific partial agonist. The compound selectively activates the G(12/13) signaling cascade resulting in platelet shape.

Preparation Note

YFLLRNP trifluoroacetate dissolves in deionized water at 1 mg/mL.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable