T123

Thioperamide maleate salt

solid

• Synonym(s): MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt
• Empirical Formula (Hill Notation): C₁₅H₂₄N₄S · C₄H₄O₄
• CAS Number: 148440-81-7
• Molecular Weight: 408.52
• MDL number: MFCD00083209
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277809
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated; under inert gas
• color: white
• solubility: H₂O: >10 mg/mL; DMSO: 12 mg/mL; ethanol: 3 mg/mL
• SMILES string: OC(=O)\C=C/C(O)=O.S=C(CC1CCCCC1)N2CCC(CC2)c3c[nH]cn3
• InChI: 1S/C16H25N3S.C4H4O4/c20-16(10-13-4-2-1-3-5-13)19-8-6-14(7-9-19)15-11-17-12-18-15;5-3(6)1-2-4(7)8/h11-14H,1-10H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChI key: REZRBLGMJZZSID-BTJKTKAUSA-N
• Gene Information: human ... HRH3(11255)

Description

Application

Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.

Biochem/physiol Actions

Potent and selective H₃ histamine receptor antagonist that crosses the blood-brain barrier.

Thioperamide is a potent and selective H₃ histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves