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SML3079

Sigma-Aldrich

Ponalrestat

≥98% (HPLC)

Synonym(s):

3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid, ICI 128436, MK538

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About This Item

Empirical Formula (Hill Notation):
C17H12BrFN2O3
CAS Number:
72702-95-5
Molecular Weight:
391.19
MDL number:
MFCD00204117
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(CC(C1=CC=CC=C1C2=O)=NN2CC3=CC=C(C=C3F)Br)=O

InChI

1S/C17H12BrFN2O3/c18-11-6-5-10(14(19)7-11)9-21-17(24)13-4-2-1-3-12(13)15(20-21)8-16(22)23/h1-7H,8-9H2,(H,22,23)

InChI key

LKBFFDOJUKLQNY-UHFFFAOYSA-N

Biochem/physiol Actions

Ponalrestat is an orally available, potent and specific inhibitor of aldehyde reductase 2 (ALR2) that blocks the conversion of glucose to sorbitol. Ponalrestat promotes root elongation through the inhibition of the flavin monooxygenase YUCCA in Arabidopsis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Guang Wang et al.
Chemical research in toxicology, 33(8), 2164-2171 (2020-07-09)
Bile acids (BAs) play essential physiological roles not only by facilitating the absorption and transport of nutrients but also by acting as a complex molecular signaling system. Reduced levels of BAs have been observed in obesity and other metabolic disorders.
Ajmer Singh Grewal et al.
Mini reviews in medicinal chemistry, 16(2), 120-162 (2015-09-10)
Diabetes mellitus occurrence has been associated to the modification of the physiological levels of glucose and is often accompanied by several long-term complications, namely neuropathy, nephropathy, retinopathy, cataract, and cardiovascular. Aldose reductase (AR) is an enzyme of aldoketo reductase super-family
Ying Zhu et al.
The Journal of biological chemistry, 294(52), 19923-19933 (2019-11-17)
Plant development is regulated by both synergistic and antagonistic interactions of different phytohormones, including a complex crosstalk between ethylene and auxin. For instance, auxin and ethylene synergistically control primary root elongation and root hair formation. However, a lack of chemical

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