SML2891
M871 trifluoroacetate
≥95% (HPLC)
Synonym(s):
Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide, TFA salt, M 871, TFA salt, M-871, TFA salt, Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Glu-His-Pro-Pro-Pro-Ala-Leu-Alal-Leu-Ala-NH2, TFA salt, WTLNSAGYLLGPEHPPPALALA-NH2, TFA salt
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About This Item
Empirical Formula (Hill Notation):
C108H163N27O28 · xC2HF3O2
Molecular Weight:
2287.61 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.
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Biochem/physiol Actions
M871 is a type 2-selective galanin receptor antagonist (GalR2/GalR1 Ki = 13.1/410 nM by competitive binding against 0.1 nM porcine galanin using membranes from CHO expressing respective human receptors; GalR2/GalR1 Ki = 2.5/1.1 nM in case of rat galanin) that potently blocks 10 nM rat galanin-induced inositol phosphate production in human GalR2-expressing CHO cells (by 100% with 0.1, 1 or 10 nM M871). M871 is widely employed in cultures (0.1 nM-2.5 μM) and in mice and rats in vivo via ip., brain region- or other site-specific injections.
Selective galanin receptor type 2 (GalR2) antagonist with in vitro and in vivo efficacy.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Penghua Fang et al.
Biochemical pharmacology, 156, 241-247 (2018-09-01)
Although recent results of our and other studies have showed that galanin (GAL) is an antidiabetic and anti-inflammatory neuropeptide, the molecular mechanism how central GAL regulates energy homeostasis and insulin sensitivity is still not fully understood. The aim of this
M871-A Novel Peptide Antagonist Selectively Recognizing the Galanin Receptor Type 2
Sollenberg UE, Lundstrom L, Bartfai T, Langel U
International Journal of Peptide Research and Therapeutics, 12, 115-119 (2006)
Mayara Machado de Souza et al.
Neuroscience letters, 681, 26-30 (2018-05-23)
Galanin is a neuropeptide distributed in human and rat brain regions that are involved with emotional regulation, such as the dorsal raphe nucleus (DRN). Galanin effects in the DRN are mediated by GAL1 and GAL2 receptors. Intracerebral infusion of a
Seu-Hwa Chen et al.
PloS one, 13(6), e0199512-e0199512 (2018-06-22)
In this study, we investigated temporal changes in galanin receptor type 2 (GalR2) expression in NF200-, galanin-, neuropeptide Y (NPY)-, and neuronal nitric oxide synthase (nNOS)-like immunoreactive (LI) dorsal root ganglion (DRG) neurons after median nerve chronic constriction injury (CCI)
Jesus-Servando Medel-Matus et al.
Experimental neurology, 289, 64-72 (2016-12-26)
Status epilepticus (SE) in rats, along with chronic epilepsy, leads to the development of behavioral impairments resembling depressive disorder and/or attention deficit/hyperactivity disorder (ADHD), thus reflecting respective comorbidities in epilepsy patients. Suppressed neurotransmitter tone in the raphe nucleus (RN)-prefrontal cortex
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