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SML0400

Sigma-Aldrich

ML204

≥98% (HPLC)

Synonym(s):

4-Methyl-2-(1-piperidinyl)-quinoline

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About This Item

Empirical Formula (Hill Notation):
C15H18N2
CAS Number:
5465-86-1
Molecular Weight:
226.32
MDL number:
MFCD00817920
UNSPSC Code:
12352200
PubChem Substance ID:
329825396
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL at warmed (clear solution)

storage temp.

2-8°C

SMILES string

Cc1cc(nc2ccccc12)N3CCCCC3

InChI

1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3

InChI key

USYRQXDHKXGTCK-UHFFFAOYSA-N

Application

4-methyl-2-(1- piperidinyl)-quinoline (ML204) has been used to attenuate Ewing sarcoma (EWS)-FLI1 activity in TC32 cells. It has also been used to attenuate scratching behavior evoked by α-Me-5HT in mice.

Biochem/physiol Actions

ML204 is a potent and selective TRPC4 channel inhibitor.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chemico-biological interactions, 260, 84-90 (2016-11-08)
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Englerin A inhibits EWS-FLI1 DNA binding in Ewing sarcoma cells
Caropreso V, et al.
The Journal of Biological Chemistry, 291(19), 10058-10066 (2016)
H M-H Chin et al.
Journal of helminthology, 91(4), 470-478 (2016-06-11)
Terrestrial arthropods host a variety of helminth parasites, yet quantifying the intensity of infection in these hosts post-mortem is challenging because carcasses may desiccate quickly. We recovered cysticercoids of Hymenolepis diminuta from desiccated flour beetle (Tribolium confusum) carcasses by modifying
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