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SAB2501514

Sigma-Aldrich

Anti-KLHL6 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-FLJ00029, Anti-kelch-like 6, Kelch-like 6 (Drosophila), Kelch-like protein KLHL6

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, canine, human, mouse

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

Q8WZ60

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KLHL6(89857)

General description

Kelch-like protein 6 (KLHL6) is a member of BTB (broad-complex, tramtrack and bric à brac)-kelch protein family. The gene encoding this protein is mapped to human chromosome 3q27. The encoded protein expression is confined to lymphoid tissue. KLHL6 exhibits high activity within the germinal center of B cells. The protein structure consists of a BTB domain at N terminal and six kelch repeats at the C terminal. KLHL6 protein is primarily expressed in human tonsil B lymphocytes.
Kelch-like protein 6 (KLHL6) plays a vital role in B-cell receptor (BCR) cell signaling and differentiation pathway of germinal center within B- cells. Aberration in the expression of this protein leads to chronic lymphocytic leukemia (CLL).

Immunogen

Peptide with sequence SERTKPRMHEFQSE, from the internal region of the protein sequence according to NP_569713.2

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Update on the Kelch-like (KLHL) gene family.
Dhanoa BS
Human Genomics (2013)
Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells.
Gupta-Rossi N
Molecular Immunology (2003)
The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation.
Kroll J
Molecular and Cellular Biology (2005)
An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes.
Sharma PR
Endocrinology (2015)
Mandeep Singh et al.
Cell, 180(5), 878-894 (2020-02-16)
Pathogenic autoantibodies arise in many autoimmune diseases, but it is not understood how the cells making them evade immune checkpoints. Here, single-cell multi-omics analysis demonstrates a shared mechanism with lymphoid malignancy in the formation of public rheumatoid factor autoantibodies responsible

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