Zinc finger CCHC-type containing 11 (ZCCHC11) is a 3′ terminal uridylyl transferase. It possesses multiple domains and has a molecular weight of about 185kDa. A fragment of the protein contains a TRF4 domain, a nucleotidyl transferase domain (NTD), two PAP-associated domains and three zinc finger domains. The ZCCHC11 gene is localized on human chromosome 1p32.3.
Immunogen
Peptide with sequence RERCPHPPRGNVSE, from the C-terminal region of the protein sequence according to NP_001009881.1; NP_056084.1; NP_001009882.1
Biochem/physiol Actions
Zinc finger CCHC-type containing 11 (ZCCHC11) has a role in the RNA-binding protein Lin28 blockade of let-7 microRNA biogenesis. It is recruited by Lin28 to pre-let-7 (let-7 precursors), where it catalyzes the addition of an oligo (U)-tail.The protein is crucial for poly (A) tail length maintenance. ZCCHC11 also has a role in regulating the stability of transcripts for interleukin-6 and other cytokines.
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Physical form
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
Mounting an effective host immune response without incurring inflammatory injury requires the precise regulation of cytokine expression. To achieve this, cytokine mRNAs are post-transcriptionally regulated by diverse RNA-binding proteins and microRNAs (miRNAs) targeting their 3' untranslated regions (UTRs). Zcchc11 (zinc-finger
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