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S4570

Sigma-Aldrich

Sulochrin

≥98% (HPLC), solid

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About This Item

Empirical Formula (Hill Notation):
C17H16O7
CAS Number:
519-57-3
Molecular Weight:
332.30
MDL number:
MFCD07370145
UNSPSC Code:
51111800
PubChem Substance ID:
24899610
Pricing and availability is not currently available.

Assay

≥98% (HPLC)

form

solid

solubility

DMF: soluble
DMSO: soluble
ethanol: soluble
methanol: soluble

antibiotic activity spectrum

fungi

Mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

COC(=O)c1cc(O)cc(OC)c1C(=O)c2c(O)cc(C)cc2O

InChI

1S/C17H16O7/c1-8-4-11(19)15(12(20)5-8)16(21)14-10(17(22)24-3)6-9(18)7-13(14)23-2/h4-7,18-20H,1-3H3

InChI key

YJRLSCDUYLRBIZ-UHFFFAOYSA-N

Application

Sulochrin was used as standard in LC/ESI for quantification of analytes from moldy food samples.[1]

Biochem/physiol Actions

Antibiotic from Aspergillus and Penicillium sp. Fungal metabolite; VEGF inhibitor and anti-angiogenic that inhibits the VEGF-induced tube formation of human umbilical vein endothelial cells.
Sulochrin, a metabolite of Aspergillus terreus and Penicillium sp., has weak anti-bacterial and anti-fungal properties. It inhibits the degranulation of eosinophils induced by the platelet activating factor.[2][3]

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
124K1393

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J Y Liu et al.
Journal of biotechnology, 114(3), 279-287 (2004-11-04)
Aspergillus fumigatus CY018 was recognized as an endophytic fungus for the first time in the leaf of Cynodon dactylon. By bioassay-guided fractionation, the EtOAc extract of a solid-matrix steady culture of this fungus afforded two new metabolites, named asperfumoid (1)
Sulochrin inhibits eosinophil degranulation.
H Ohashi et al.
The Journal of antibiotics, 50(11), 972-974 (1998-05-21)
H Ohashi et al.
Bioorganic & medicinal chemistry letters, 9(14), 1945-1948 (1999-08-18)
Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and
Robin D Couch et al.
Journal of biotechnology, 108(2), 171-178 (2004-05-08)
Elimination of undesirable co-metabolites from industrial fermentations is often required due to the toxicities associated with the contaminants and/or due to difficulties in removing the contaminants during downstream processing. Sulochrin is a co-metabolite produced during the Aspergillus terreus lovastatin fermentation.
Syo Nakajima et al.
Biochemical and biophysical research communications, 440(4), 515-520 (2013-10-09)
Hepatitis C virus (HCV) is a major causative agent of hepatocellular carcinoma. Although various classes of anti-HCV agents have been under clinical development, most of these agents target RNA replication in the HCV life cycle. To achieve a more effective
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