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Key Documents

P5806

Sigma-Aldrich

Pasteurella multocida toxin

lyophilized powder

Synonym(s):

PMT

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About This Item

CAS Number:
129876-91-1
MDL number:
MFCD00131803
UNSPSC Code:
12352200
NACRES:
NA.77

sterility

sterile-filtered

Quality Level

200

form

lyophilized powder

packaging

vial of 50 μg toxin (Also contains 10 mM Tris, 0.1 M NaCl, and 0.1% sucrose, pH 8.3.)

storage temp.

−20°C

Biochem/physiol Actions

Pasteurella multocida toxin (PMT) is a bacterial protein toxin produced by few P. multocida serotype A and D strains. It acts as an effective mitogen in numerous cell types in vitro. PMT inhibits osteoblast differentiation by activating the Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK) pathway. Infections of PMT cause atrophic rhinitis in pigs and by local dermatonecrosis, respiratory disease in cattle and rabbits. PMT is also a pathogenic agent of dermatonecrosis and bacteremia in humans.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The Pasteurella multocida toxin is encoded within a lysogenic bacteriophage
Pullinger GD, et al.
Molecular Microbiology, 51(1), 255-269 (2004)
Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and-independent mechanisms involvement of Gq but not G11
Zywietz A, et al.
The Journal of biological chemistry, 276(6) (2001)
Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formation
Harmey D, et al.
Journal of Bone and Mineral Research, 19(4), 661-670 (2004)

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