G8279
Gum guaiac
crude colorimetric peroxidase substrate
Synonym(s):
Guaiac, Guaiacum, Resin guaiac
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About This Item
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form
powder
mp
85 °C (dec.) (lit.)
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Application
Gum guaiac is a tree resin and crude source of 2,5-di-(4-hydroxy-3-methoxyphenyl)-3,4-dimethylfuran (α-guaiaconic acid). The phenolic α-guaiaconic acid acts as a colorimetric peroxidase substrate. When reacted with an organic or inorganic oxidizing agent, the α-guaiaconic acid is oxidized to a blue-colored quinone. The guaiac reaction has been used to detect trace amounts of heme from hemoglobin in the presence of peroxide.
The Nobles test can be performed using 67% (w/v) gum guaiac diluted in 96% ethanol to analyze the level of extracellular oxidase production
Other Notes
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Hermann Brenner et al.
European journal of cancer (Oxford, England : 1990), 49(14), 3049-3054 (2013-05-28)
There is increasing evidence that faecal immunochemical tests (FITs) for haemoglobin offer a number of advantages over traditional guaiac based faecal occult blood tests (gFOBTs). However, evidence on diagnostic performance from direct comparisons with colonoscopy findings in all participants in
Mechanism of Oxidation in the Plant. Part II: An Investigation of Substances which are capable of behaving as Peroxydases.
P H Gallagher
The Biochemical journal, 18(1), 29-38 (1924-01-01)
C K Palmer et al.
British journal of cancer, 110(7), 1705-1711 (2014-03-13)
Screening for bowel cancer using the guaiac faecal occult blood test offered by the NHS Bowel Cancer Screening Programme (BCSP) is taken up by 54% of the eligible population. Uptake ranges from 35% in the most to 61% in the
S Webendörfer et al.
Deutsche medizinische Wochenschrift (1946), 139(3), 79-83 (2013-10-04)
If the diagnosis is made early the cure rate of bowel cancer is more than 90 %. Occupational preventative medical care required by law and carried out by company physicians can be supplemented by a medical consultation and by simple screenings
Isolation and characterization of α-guaiaconic acid and the nature of guaiacum blue.
Kratochvil, J.F., et al.
Phytochemistry, 10, 2529-2531 (1971)
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