C4428
Cathepsin G from human leukocytes
lyophilized powder, ≥60 units/mg protein (Bradford)
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32
Pricing and availability is not currently available.
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biological source
human leucocytes
Quality Level
form
lyophilized powder
specific activity
≥60 units/mg protein (Bradford)
mol wt
23-30 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CTSG(1511)
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General description
Application
Biochem/physiol Actions
Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism.[1] Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors.[6] It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells.[2] Cathepsin G is associated with autoimmunity and cancer.[7] It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.[8]
Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.
Unit Definition
One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide at pH 7.5 at 37 °C.
Physical form
Lyophilized from 0.5 M pyridinium acetate, pH 5.3.
inhibitor
substrate
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Delivery and therapeutic potential of human granzyme B
Kurschus FC and Jenne DE
Immunological Reviews, 235(1), 159-171 (2010)
Cathepsin G: roles in antigen presentation and beyond
Burster T, et al.
Molecular Immunology, 47(4), 658-665 (2010)
Structure, function, and control of neutrophil proteinases
Travis J
The American Journal of Medicine, 84(6), 37-42 (1988)
P I Bird
Immunology and cell biology, 77(1), 47-57 (1999-04-02)
Caspase activation and apoptosis can be initiated by the introduction of serine proteinases into the cytoplasm of a cell. Cytotoxic lymphocytes have evolved at least one serine proteinase with specific pro-apoptotic activity (granzyme B), as well as the mechanisms to
Protein Degradation in Health and Disease (2009)
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