AV47974

Anti-NDRG1 (AB1) antibody produced in rabbit

IgG fraction of antiserum

• Synonym(s): Anti-CAP43, Anti-CMT4D, Anti-DRG1, Anti-GC4, Anti-HMSNL, Anti-N-Myc downstream Regulated gene 1, Anti-NDR1, Anti-NMSL
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 43 kDa
• species reactivity: human, dog, bovine
• concentration: 0.5 mg - 1 mg/mL
• technique(s): western blot: suitable
• NCBI accession no.: NP_001128714
• UniProt accession no.: Q92597
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... NDRG1(10397)

Description

General description

N-myc downstream regulated 1 (NDRG1) is a cytoplasmic hydrolase that modulates stress, hormonal responses, cell growth, differentiation and LDL receptor trafficking. It mediates antimetastatic effects in cancer cells and is downregulated in prostate cancer cells.
Rabbit Anti-NDRG1 antibody recognizes canine, chicken, mouse, zebrafish, bovine, human, and rat NDRG1.

Immunogen

Synthetic peptide directed towards the C terminal region of human NDRG1

Application

Rabbit Anti-NDRG1 antibody is suitable for western blot applications at a concentration of western blot applications at a concentration of 2.5 μg/ml.

Biochem/physiol Actions

NDRG1 is a member of the N-myc downregulated protein family which belongs to the alpha/beta hydrolase superfamily. NDRG1 is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. Mutation in its gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom.This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. Mutation in this gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom.

Sequence

Synthetic peptide located within the following region: GSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGA

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable