Fused in sarcoma (FUS); translocated in LipoSarcoma (TLS) is a component of a fusion pro-oncogene resulting from a chromosomal translocation seen in liposarcomas. FUS/TLS belongs to a sub-family of RNA binding proteins that interacts with RNA, ssDNA, and dsDNA. FUS/TLS is involved in unique functions in mRNA processing and transport, transcriptional regulation and maintenance of genomic stability. FUsed in sarcoma (FUS); Translocated in LipoSarcoma (TLS) is a multifunctional protein implicated in a wide range of cellular processes, including transcription and mRNA processing, as well as in both cancer and neurological disease. Mutations in the fused in sarcoma (FUS) gene are linked to a form of familial amyotrophic lateral sclerosis (ALS), ALS6.
Specificity
Anti-FUS/TLS polyclonal antibody reacts with chicken, bovine, human, mouse, and rat FUsed in sarcoma/translocated in LipoSarcoma proteins.
Immunogen
The immunogen for anti-FUS antibody: synthetic peptide derected towards the N terminal of human FUS
Application
Anti-FUS/TLS polyclonal antibody is used to tag FUsed in sarcoma/translocated in LipoSarcoma proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the possible roles of FUsed in sarcoma/translocated in LipoSarcoma proteins in transcription and mRNA processing and amyotrophic lateral sclerosis, ALS6
Sequence
Synthetic peptide located within the following region: MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGY
Physical form
Lyophilized from PBS buffer with 2% sucrose
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 44(27) (2024-05-02)
Aberrant condensation and localization of the RNA-binding protein (RBP) fused in sarcoma (FUS) occur in variants of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Changes in RBP function are commonly associated with changes in axonal cytoskeletal organization and branching
Recently mutations in ubiquilin-2 were identified in patients with amyotrophic lateral sclerosis (ALS) and ALS/dementia providing direct evidence for the importance of this protein in neurodegenerative diseases. Histological studies have suggested that ubiquilin-1/-2 are associated with various pathological inclusions including
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