A4316
Anantin from Streptomyces coerulescens
≥90% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C90H111N21O24
CAS Number:
Molecular Weight:
1870.97
MDL number:
UNSPSC Code:
12352200
Assay
≥90% (HPLC)
storage temp.
−20°C
Amino Acid Sequence
Cyclo(Gly-Phe-Ile-Gly-Trp-Gly-Asn-β-Asp)-Ile-Phe-Gly-His-Tyr-Ser-Gly-Asp-Phe
Biochem/physiol Actions
Competitive antagonist at atrial natriuretic peptide NPR-A receptors.
Other Notes
A cyclic peptide
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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S Nachshon et al.
The American journal of physiology, 268(3 Pt 1), E428-E432 (1995-03-01)
Atrial natriuretic peptide (ANP) is a hormone-secreted predominantly by atrial myocytes. ANP exerts many of its actions via activation of the particulate guanylyl cyclase receptor ANPR-A and the formation of guanosine 3',5'-cyclic monophosphate (cGMP), which serves as a second messenger
Cell-specific manipulation of second messengers; a toolbox for integrative physiology in Drosophila.
Martin Kerr et al.
Current biology : CB, 14(16), 1468-1474 (2004-08-25)
Every living cell must detect, and respond appropriately to, external signals. The functions of intracellular second messengers, such as guanosine 3'5'-cyclic monophosphate (cGMP), adenosine 3'5'-cyclic monophosphate (cAMP), and intracellular calcium, are thus intensively studied. However, artifact-free manipulation of these messengers
Neurohumoral mechanism in the natriuretic action of intracerebroventricular administration of renin.
Lida Zavala et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 5(1), 39-44 (2004-05-12)
Intracerebroventricular (i.v.t.) administration of renin (R) decreases urinary volume and increases urinary sodium excretion. We investigated whether i.v.t.-R-induced natriuresis could be associated with the release of atrial natriuretic peptide (ANP), its interaction with renal ANP-A receptors (ANPR-A) and the subsequent
R Vos et al.
Photochemistry and photobiology, 60(1), 24-32 (1994-07-01)
Anantin is a heptadecapeptide in which the C-terminal peptide chain pierces the covalently cyclized peptide ring formed by an amide link between the alpha-NH2 end group and the beta-carboxyl group of Asp(8). It contains a tryptophan and a histidine at
Li-Hui Cao et al.
Brain research bulletin, 71(4), 410-415 (2007-01-09)
By the patch clamp technique, whole-cell currents induced by brain natriuretic peptide (BNP) from isolated bullfrog retinal Müller cells were studied. Application of 100 nM BNP induced a sustained inward current from these cells with a reversal potential of about
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