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SMB01386

Sigma-Aldrich

6-Formylpterin

greener alternative

≥95% (HPLC)

Synonym(s):

6-FP, 2-Amino-4-hydroxy-6-formylpteridine, 2-Amino-6-formylpteridin-4-one, Pterin-6-aldehyde

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About This Item

Empirical Formula (Hill Notation):
C7H5N5O2
CAS Number:
712-30-1
Molecular Weight:
191.15
MDL number:
MFCD20924530
UNSPSC Code:
12352005
NACRES:
NA.77

biological source

synthetic

Quality Level

100

Assay

≥95% (HPLC)

form

solid

greener alternative product score

old score: 59
new score: 52
Find out more about DOZN™ Scoring

greener alternative product characteristics

Safer Solvents and Auxiliaries
Reduce Derivatives
Design for Degradation
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

application(s)

metabolomics

greener alternative category

, Re-engineered

storage temp.

2-8°C

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General description

6-Formylpterin is a Vitamin B9 (folate) metabolite and ligand to MHC class I-related protein 1 (MR1) antigens presented on mucosal-associated invariant T (MAIT) cells.
We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to the category of Re-engineered products, showing key improvements in Green Chemistry Principles “Safer Solvents and auxiliaries”, “Reduce Derivatives”, and “Design for Degradation”. Click here to view its DOZN scorecard.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000359927
0000359927
0000251500
0000264438

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Hamish E G McWilliam et al.
Trends in immunology, 38(9), 679-689 (2017-07-10)
Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes restricted by the antigen (Ag)-presenting molecule MHC class I (MHC I)-related protein 1 (MR1). The Ags presented by MR1 are vitamin B-related Ags (VitBAgs), 'building-block' metabolites of riboflavin that are synthesized by
Sidonia B G Eckle et al.
The Journal of experimental medicine, 211(8), 1585-1600 (2014-07-23)
Mucosal-associated invariant T (MAIT) cells express an invariant T cell receptor (TCR) α-chain (TRAV1-2 joined to TRAJ33, TRAJ20, or TRAJ12 in humans), which pairs with an array of TCR β-chains. MAIT TCRs can bind folate- and riboflavin-based metabolites restricted by
Lars Kjer-Nielsen et al.
Nature, 491(7426), 717-723 (2012-10-12)
Antigen-presenting molecules, encoded by the major histocompatibility complex (MHC) and CD1 family, bind peptide- and lipid-based antigens, respectively, for recognition by T cells. Mucosal-associated invariant T (MAIT) cells are an abundant population of innate-like T cells in humans that are

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