PHL82530

(−)-Englerin A

phyproof^® Reference Substance

• Empirical Formula (Hill Notation): C₂₆H₃₄O₆
• CAS Number: 1094250-15-3
• Molecular Weight: 442.54
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: primary reference standard
• product line: phyproof^® Reference Substance
• Assay: ≥95.0% (HPLC)
• manufacturer/tradename: PhytoLab
• application(s): food and beverages
• format: neat
• SMILES string: O1C2(C3C(C(C1(CC2OC(=O)CO)C(C)C)OC(=O)\C=C\c4ccccc4)C(CC3)C)C
• InChI: 1S/C26H34O6/c1-16(2)26-14-20(30-22(29)15-27)25(4,32-26)19-12-10-17(3)23(19)24(26)31-21(28)13-11-18-8-6-5-7-9-18/h5-9,11,13,16-17,19-20,23-24,27H,10,12,14-15H2,1-4H3/b13-11+
• InChI key: GACOFEKSDCOVMV-ACCUITESSA-N

Description

General description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Application

• Englerin A as a Potent Selective Inhibitor of Renal Cancer: Englerin A has demonstrated remarkable efficacy in inducing cytotoxicity in renal cancer cells through the hyperphosphorylation of Hsp27 and as a promising antitumor agent in cancer pharmacotherapy (Neo et al., 2022).


• Natural Product TRPC4 Activator: Englerin A′s role in inhibiting T-type voltage-gated calcium channels showcases its unique mechanism of action as a natural product activator of TRPC4/TRPC5 ion channels, offering new avenues for therapeutic interventions in cancer biology (Wardas et al., 2023).

Legal Information

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable