Journal of hepatology, 15(1-2), 144-146 (1992-05-01)
Fipexide belongs to a new class of cognition activators and is noted for its lack of amphetamin-like side effects. We describe three patients who developed fulminant hepatic failure less than 2 months after beginning fipexide administration. The mean interval from
Acta physiologica et pharmacologica Bulgarica, 14(4), 36-41 (1988-01-01)
Experiments on albino rats were carried out to study the effects of the nootropic drugs piracetam, aniracetam, meclofenoxate and fipexide on the DA-beta-hydroxylase inhibitor diethyldithiocarbamate- and the alpha 2-adrenoceptor agonist clonidine-impaired cognitive functions. The changes in memory were studied by
The release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal slices is affected by exposure to amphetamine and fipexide (chloro-4-phenoxy)-2-acetyl-1-(methylene-dioxy 3, 4-benzyl-4-piperazine) a psychostimulant drug with mild dopaminomimetic activity. Both amphetamine and fipexide inhibited in vitro the release of ME-IR.
Rapid communications in mass spectrometry : RCM, 24(9), 1241-1250 (2010-04-15)
Drug bioactivation leading to the formation of reactive species capable of covalent binding to proteins represents an important cause of drug-induced toxicity. Reactive metabolite detection using in vitro microsomal incubations is a crucial step in assessing potential toxicity of pharmaceutical
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