10784

Antipyrine

tested according to Ph. Eur.

• Synonym(s): Phenazonum, 2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one, Phenazone
• Empirical Formula (Hill Notation): C₁₁H₁₂N₂O
• CAS Number: 60-80-0
• Molecular Weight: 188.23
• Beilstein: 157775
• EC Number: 200-486-6
• MDL number: MFCD00003146
• UNSPSC Code: 41116107
• PubChem Substance ID: 329749157
• NACRES: NA.21

Properties

• Agency: USP/NF; tested according to Ph. Eur.
• Quality Level: 100
• form: crystals and lumps; powder
• mp: 109-111 °C (lit.)
• solubility: H₂O: soluble 1 gm in less than 1ml; alcohol: soluble 1 gm in 1.3 ml; chloroform: soluble 1 gm in 1 ml; diethyl ether: soluble 1 gm in 43 ml
• application(s): pharmaceutical (small molecule)
• SMILES string: CN1N(C(=O)C=C1C)c2ccccc2
• InChI: 1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3
• InChI key: VEQOALNAAJBPNY-UHFFFAOYSA-N
• Gene Information: human ... PTGS1(5742)

Description

Application

Antipyrine has been used for immunoblotting. It has also been used as an internal reference marker for studying the transport characteristics of platinum-containing drug, cisplatin in the human placenta in vitro.

Biochem/physiol Actions

Antipyrine also referred to as phenazone or phenazonum is an anti-inflammatory agent that possesses analgesic, antipyretic and platelet-inhibitory actions.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves