Paired mesoderm homeobox protein 2B (PHOX2B), also known as Neuroblastoma Phox (NBPhox), PHOX2B homeodomain protein, and Paired-like homeobox 2B is a paired-homeodomain transcription factor that maintains the noradrenergic phenotype during embryogenesis. PHOX2 proteins help regulate endogenous hydroxylases in neural crest cells and aid in sympathetic neuron generation. PHOX2A controls only the differentiation of the main noradrenergic center of the human brain, while PHOX2B is required for the differentiation of all central and nonperipheral noradrenergic centers. PHOX2B is expressed in neuroblastoma, brain and adrenal gland. PHOX2B defects can cause congenital central hypoventilation syndrome (CCHS) and susceptibility to neuroblastoma type 2 (NBLST2). PHOX2 regulation may have therapeutic potential in aging or degenerative noradrenergic neuron disorders.
Immunogen
KLH-conjugated linear peptide corresponding to human PHOX2B.
Application
Detect Phox2a using this rabbit polyclonal antibody, Anti-PHOX2B Antibody validated for use in western blotting.
Research Category Stem Cell Research
Research Sub Category Pluripotent & Early Differentiation
Quality
Evaluated by Western Blotting in HEK293 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected PHOX2B in 15 µg of HEK293 cell lysate.
Target description
~22 kDa observed. Uncharacterized bands may appear in some lysate(s).
Physical form
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control HEK293 cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
