5.05818

Scopolamine Hydrobromide

• Synonym(s): Scopolamine Hydrobromide, Muscarinic Acetylcholine Receptor (mAChR) Antagonist, Scopolamine, Levo-duboisine, Hyoscine, Scopoderm
• Empirical Formula (Hill Notation): C₁₇H₂₁NO₄ · xHBr
• CAS Number: 114-49-8
• Molecular Weight: 303.35 (free base basis)
• MDL number: MFCD00012647
• UNSPSC Code: 12352116
• NACRES: NA.77

Properties

• Assay: ≥99% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: H₂O: 100 mM
• storage temp.: 2-8°C
• SMILES string: [Br].N1([C@@H]2[C@@H]3O[C@@H]3[C@@H]1CC(C2)OC(=O)[C@H](CO)c4ccccc4)C
• InChI: 1S/C17H21NO4.Br/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;/t11?,12-,13+,14+,15-,16+;/m1./s1
• InChI key: XUZPYCBMTSSDHK-AKTDCHNFSA-N

Description

General description

A competitive, non-selective antagonist for muscarinic acetylcholine receptors (mAChR). Most effective at treating motion sickness. It is also a research tool for inducing memory impairment in vivo. Frequently used in researches related to learning, memory and Alzheimer′s dementia.

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Klinkenberg, I., et al. 2010. Neurosci Biobehav Rev34, 1307.
Aparkes. W. 1995. Psychopharmacologia.7, 1.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300 + H310 + H330
• Precautionary Statements: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3