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Key Documents

453710

Sigma-Aldrich

MEK Inhibitor Set

The MEK Inhibitor Set controls the biological activity of MEK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

shipped in

ambient

storage temp.

−20°C

General description

Contains 5 mg of PD 98059 (Cat. No. 513000), 1 mg of U0126 (Cat. No. 662005), and 1 mg of the negative control U0124 (Cat. No. 662006). Supplied with a data sheet.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
MEK 1, MEK 2
Target IC50: 72 nM, 58 nM

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

DeSilva, D. R., et al. 1998. J. Immunol.160, 4175.
Favata, M. F., et al. 1998. Biochem J.273, 18623.
Kulz, D., et al. 1998. J. Biol. Chem.273, 13645.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Questions

  1. It would be greatly appreciated if you could provide the references for the individual MEK inhibitors, as they are not available through the typical online databases. Thank you.

    1 answer

    1. Some references are listed on each product’s corresponding Sigma-Aldrich website (see links below) under the section “Other Notes”. Many additional references for 513000 & 662005 are listed under the section “PEER REVIEWED PAPERS”.

      Copyright laws prohibit providing complete copies of reference articles.

      https://www.sigmaaldrich.com/product/mm/513000
      https://www.sigmaaldrich.com/product/mm/662005
      https://www.sigmaaldrich.com/product/mm/662006

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