407616
IL-1R Antagonist
The IL-1R Antagonist, also referenced under CAS 566914-00-9, controls the biological activity of IL-1R.
Synonym(s):
IL-1R Antagonist, BB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic
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About This Item
Empirical Formula (Hill Notation):
C18H26N2O2
CAS Number:
Molecular Weight:
302.41
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
Assay
≥95% (HPLC)
form
oil
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
colorless
solubility
DMSO: 10 mg/mL
ethanol: soluble
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable, end protected L-valyl derivative modeled on the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
A cell-permeable, end protected L-valyl derivative of the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
TIR domain-mediated MyD88/IL1-RI interaction
TIR domain-mediated MyD88/IL1-RI interaction
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Bartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7971.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Shiqin Xiong et al.
Arteriosclerosis, thrombosis, and vascular biology, 41(11), 2773-2785 (2021-09-10)
[Figure: see text].
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