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04-1470

Sigma-Aldrich

Anti-OX40L (CD252) Antibody, clone RM134L

clone RM134L, from rat

Synonym(s):

Tumor necrosis factor ligand superfamily member 4, OX40 ligand, OX40L, CD252

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rat

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

RM134L, monoclonal

species reactivity

mouse

technique(s)

flow cytometry: suitable
immunohistochemistry: suitable

isotype

IgG2bκ

NCBI accession no.

NP_033478

UniProt accession no.

P43488

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Tnfsf4(22164)

General description

OX40L (Tumor necrosis factor ligand superfamily member 4; or CD252) is the endogenous ligand of the OX40 receptor. OX40 is localized on activated T-cells and propagates the immune response by promoting division and survival of T-cells, thereby increasing the population of memory CD4 and CD8 T cells produced in response to antigen detection. The OX40/OX40L may also regulate cytokine production and suppress the activity of T-regulatory cells. OX40/OX40L is therefore an important mediator of the immune response. Previous studies have suggested that OX40 signaling maybe involved in the development of autoimmune diseases.

Specificity

This antibody recognizes the extracellular domain of OX40L.

Immunogen

Mouse OX40L cDNA-transfected NRK cells

Application

Anti-OX40L (CD252) Antibody, clone RM134L detects level of OX40L (CD252) & has been published & validated for use in Flow Cytometry & IHC.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in mouse lung tissue. (Hoshino, A., et al. (2003). Eur. J. Immunol. 33:861–869.)

Quality

Evaluated by Flow Cytometry in mouse OX40L/L5178Y cells.

Flow Cytometry Analysis: 10 µg of this antibody detected OX40L in mouse OX40L/L5178Y cells.

Target description

22 kDa calculated

Physical form

Format: Purified

Analysis Note

Control
Mouse OX40L/L5178Y cells

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Akihiko Hoshino et al.
European journal of immunology, 33(4), 861-869 (2003-04-03)
Bronchial asthma is characterized by massive infiltration of eosinophils and airway hyperreactivity (AHR), which are caused by overproduction of Th2 cytokines (IL-4, IL-5, and IL-13) by allergen-specific T cells. We recently demonstrated a critical contribution of OX40 ligand (OX40L) to

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