03-0202-00

SMC^® Human NF-L High Sensitivity Immunoassay Kit

kit sufficient for 96 wells

• Synonym(s): NF-L Single Molecule Counting kit, NF-L immunoassay kit, NF-L ultra-sensitive immunoassay, Neurofilament Light Chain kit, NfL kit
• UNSPSC Code: 12161503
• NACRES: NA.77

Properties

• Quality Level: 200
• usage: kit sufficient for 96 wells
• species reactivity: human
• manufacturer/tradename: SMC^®
• parameter: 25 μL sample volume (CSF); 50 μL sample volume (serum and plasma)
• assay range: intra-assay cv: ≤10%; (n=3); sensitivity: 0.87 pg/mL; standard curve range: 0.43-1500 pg/mL; linearity: 80-120%; recovery range: 80-120%; inter-assay cv: ≤11%; (n=3)
• technique(s): single molecule counting: suitable
• input: plasma (K2 EDTA); cerebrospinal fluid (CSF); serum
• shipped in: wet ice
• storage temp.: 2-8°C

Description

General description

Neurofilament Light Chain (NF-L) is a low molecular weight member of a family of proteins involved in axonal development and function. NF-L accumulation is viewed as a telltale sign of axonal damage in the brain, and is a key marker in a wide range of neurodegenerative diseases, especially as a blood-based biomarker. We are proud to aid these efforts by offering the new SMC^® Human NF-L High Sensitivity Immunoassay Kit. By coupling this assay with the powerful state-of-the-art SMCxPRO^® detection system, researchers can accurately assess NF-L concentrations even in low abundance in human serum, plasma, and CSF samples, enabling studies that examine the relevance of this key analyte from health to disease.

Research Category:
Neuroscience
Neurological

Research Sub-Category:
Alzheimer′s Disease
Aging
Nervous System
Neurodegenerative Diseases
Neurofilament & Neuron Metabolism
Neuronal & Glial Markers
Neuroregenerative Medicine
Neuroscience

Specificity

This assay was tested for cross-reactivity with Neurofilament Medium Chain (NF-M), Neurofilament Heavy Chain (NF-H), phospho-Tau (T181), total Tau, and Glial Fibrillary Acidic Protein (GFAP). No cross-reactivity was detected with these analytes.

Application

Used for ultrasensitivite quantification of Human NF-L in human serum, plasma, and CSF.

Features and Benefits

This SMC^® kit features:

• Accurate and reproducible performance on the state-of-the-art SMCxPRO^® ultrasensitive immunoassay system.
• Compatiblity with automated liquid handling

Legal Information

SMC is a registered trademark of Singulex

SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H302 + H332,H311,H319,H360FD,H412
• Precautionary Statements: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects