A76427
3-Aminopropionitrile fumarate salt
≥99%
Synonym(s):
β-Alaninenitrile
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Assay
≥99%
mp
177 °C (dec.) (lit.)
SMILES string
NCCC#N.NCCC#N.OC(=O)\C=C\C(O)=O
InChI
1S/C4H4O4.2C3H6N2/c5-3(6)1-2-4(7)8;2*4-2-1-3-5/h1-2H,(H,5,6)(H,7,8);2*1-2,4H2/b2-1+;;
InChI key
NYMXYZMHOZAPHQ-SEPHDYHBSA-N
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Biochem/physiol Actions
In mammals, metabolism of 3-aminopropionitrile leads to release of cyanide ions. Metabolic activity is localized in the microsomal fraction of the liver, and is believed to proceed through a free-radical pathway.
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Description
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Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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E Baden et al.
Journal de biologie buccale, 10(3), 227-235 (1982-09-01)
The effects of chronic toxicity of beta-aminoproprionitrile (BAPN) on the lingual artery and aorta of the rat were compared. Thirty-two three week old weanling male white Wistar rats were given 1 g/kg/day (for five days weekly) of a 40% saturated
Possibilities for the therapeutic control of fibrosis.
C I Levene
The British journal of dermatology, 112(3), 363-371 (1985-03-01)
Hirotaka Nagashima et al.
Journal of vascular surgery, 36(4), 818-823 (2002-10-09)
Cystic medial degeneration (CMD) is a histologic abnormality that is common in aortic diseases such as aortic dilation, aneurysm, or dissection. Although little is known about the mechanism underlying CMD, we have previously demonstrated that angiotensin II signaling via angiotensin
D L Hoffman et al.
Experimental and molecular pathology, 39(2), 154-162 (1983-10-01)
beta-Aminopropionitrile as free base (BAPN) was applied onto the incised or intact skin of rats at the dose of 5, 20, 100, and 200 microliters for 9 days, twice daily. Breaking strength of the skin wound or intact skin was
G Granström et al.
Scandinavian journal of plastic and reconstructive surgery and hand surgery, 26(1), 13-20 (1992-01-01)
Cleft palate was induced in 420 embryos of Sprague-Dawley rats with a single oral dose of 600 mg/kg beta-aminoproprionitrile (BAPN) on embryonal day 15, 7 hours. The cleft palate was accompanied by a pathological differentiation pattern of various isoenzymes in
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