The aim was to assess the in vitro effect of glycerol, ethylene glycol or acetamide on frozen-thawed ram spermatozoa. Aliquots of each sixteen ejaculates from four rams of the Morada Nova breed were diluted in Tris-egg yolk with glycerol (5%)
European journal of medicinal chemistry, 46(10), 4853-4858 (2011-08-20)
KX2-391 (KX-01/Kinex Pharmaceuticals), N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide, is a highly selective Src substrate binding site inhibitor. To understand better the role of pyridine ring and N-benzylsubstitution in KX2-391 and establish the structure-activity relationship, a number of N-benzyl substituted (((2-morpholinoethoxy)phenyl)thiazol-4-yl)acetamide derivatives containing thiazole instead
Physical chemistry chemical physics : PCCP, 13(33), 15211-15220 (2011-07-16)
Insights into the formation of hydrogen bonded clusters are of outstanding importance and quantum chemical calculations play a pivotal role in achieving this understanding. Structure and energetic comparison of linear, circular and standard forms of (acetamide)(n) clusters (n = 1-15)
Colloids and surfaces. B, Biointerfaces, 102, 95-101 (2012-09-26)
Individual dispersion of single-walled carbon nanotubes (SWNTs) in biocompatible media is of particular interest for diverse biomedical and nanomedicine applications. Herein we present, for the first time, a neutral pH water-soluble chitosan derivative, chitosan-hydroxyphenyl acetamide (CHPA), prepared by functionalizing the
Proceedings of the National Academy of Sciences of the United States of America, 109(6), 1937-1942 (2012-02-07)
We apply a free energy perturbation simulation method, free energy perturbation/replica exchange with solute tempering, to two modifications of protein-ligand complexes that lead to significant conformational changes, the first in the protein and the second in the ligand. The approach
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