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557811

Sigma-Aldrich

2,4-Diisopropylphenol

98%

Synonym(s):

2,4-Bis(1-methylethyl)phenol, 2,4-Bis(propan-2-yl)phenol, 2,4-Di(propan-2-yl)phenol

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About This Item

Linear Formula:
[(CH3)2CH]2C6H3OH
CAS Number:
2934-05-6
Molecular Weight:
178.27
EC Number:
220-906-1
MDL number:
MFCD01707536
UNSPSC Code:
12352100
PubChem Substance ID:
24879699
NACRES:
NA.22

Assay

98%

refractive index

n20/D 1.5130 (lit.)

bp

79-80 °C (lit.)

density

0.948 g/mL at 25 °C (lit.)

SMILES string

CC(C)c1ccc(O)c(c1)C(C)C

InChI

1S/C12H18O/c1-8(2)10-5-6-12(13)11(7-10)9(3)4/h5-9,13H,1-4H3

InChI key

KEUMBYCOWGLRBQ-UHFFFAOYSA-N

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General description

2,4-Diisopropylphenol, commonly known as 2,4-propofol, is an isomeric form of propofol. EC50 Microtox (5min, 25°C) assay value of 2,4-diisopropylphenol is 2x10-4mM. It is formed as one of the reaction products from the reaction between boron fluoride with isopropyl phenyl ether.

Application

2,4-Diisopropylphenol may be used in the preparation of N,N-bis(3,5-diisopropyl-2-hydroxybenyl)-N′,N′-dimethyl-1,2-diaminoethane.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

230.0 °F - closed cup

Flash Point(C)

110 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Organic Reactions with Boron Fluoride. V. The Rearrangement of Isopropylphenol, o-, m-and p-Cresyl Ethers.
Sowa FJ, et al.
Journal of the American Chemical Society, 55(8), 3402-3407 (1933)
T P Heil et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 24(4), 349-360 (1989-08-01)
EC50 Microtox (5 min, 25 degrees C) assay values for 2-isopropylphenol, 3-isopropylphenol, 4-isopropylphenol, 2,4-diisopropylphenol, 2,5-diisopropylphenol 2,6-diisopropylphenol, 3,5-diisopropylphenol, carvacrol, thymol, thiophenol, and thiocresol ranged from 2 x 10(-2) mM for thymol (least toxic) to 2 x 10(-4) mM for 2,4-diisopropylphenol and
rac-Lactide polymerization using aluminum complexes bearing tetradentate phenoxy-amine ligands.
Tang Z and Gibson VC.
European Polymer Journal, 43(1), 150-155 (2007)
Tomoaki Urabe et al.
European journal of pharmacology, 884, 173303-173303 (2020-07-19)
Propofol, most frequently used as a general anesthetic due to its versatility and short-acting characteristics, is thought to exert its anesthetic actions via GABAA receptors; however, the precise mechanisms of its adverse action including angialgia remain unclear. We examined the
Shanker Karunanithi et al.
eNeuro, 7(1) (2020-02-06)
Propofol is the most common general anesthetic used for surgery in humans, yet its complete mechanism of action remains elusive. In addition to potentiating inhibitory synapses in the brain, propofol also impairs excitatory neurotransmission. We use electrophysiological recordings from individual
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