Skip to Content
Merck
All Photos(1)

Documents

542709

Sigma-Aldrich

2,6-Difluorobenzenesulfonamide

97%

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
F2C6H3SO2NH2
CAS Number:
Molecular Weight:
193.17
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

97%

mp

187-191 °C (lit.)

SMILES string

NS(=O)(=O)c1c(F)cccc1F

InChI

1S/C6H5F2NO2S/c7-4-2-1-3-5(8)6(4)12(9,10)11/h1-3H,(H2,9,10,11)

InChI key

RVVVGGCOFWWDEL-UHFFFAOYSA-N

General description

2,6-Difluorobenzenesulfonamide is a fluorinated benzenesulfonamide that can be prepared by reacting 2,6-difluorobenzenesulfonyl chloride with 29% ammonium hydroxide. It forms complexes with human carbonic anhydrase II (HCA). X-ray crystal structure of these complexes have been studied.

Application

2,6-Difluorobenzenesulfonamide can be prepared from N-(4-chlorophenyl)-N′-[(2,6-di fluorophenyl)-sulfonyl]urea.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Insect growth regulators. Analogs of TH-6038 and TH-6040.
Oliver JE, et al.
Journal of Agricultural and Food Chemistry, 24(5), 1065-1068 (1976)
Shruthi Vaidhyanathan et al.
The Journal of pharmacology and experimental therapeutics, 356(2), 251-259 (2015-11-26)
Small molecule inhibitors targeting the mitogen-activated protein kinase pathway (Braf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase) have had success in extending survival for patients with metastatic melanoma. Unfortunately, resistance may occur via cross-activation of alternate signaling pathways. One approach to overcome
Vijay M Krishnamurthy et al.
Chemistry, an Asian journal, 2(1), 94-105 (2007-04-19)
This paper describes a calorimetric study of the association of a series of seven fluorinated benzenesulfonamide ligands (C6H(n)F(5-n)SO2NH2) with bovine carbonic anhydrase II (BCA). Quantitative structure-activity relationships between the free energy, enthalpy, and entropy of binding and pKa and log
Shruthi Vaidhyanathan et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(8), 1292-1300 (2014-05-31)
Brain metastases are a major cause of mortality in patients with advanced melanoma. Adequate brain distribution of targeted agents for melanoma will be critical for treatment success. Recently, improvement in overall survival led to US Food and Drug Administration (FDA)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service