Recommended Products
Assay
97%
mp
187-191 °C (lit.)
SMILES string
NS(=O)(=O)c1c(F)cccc1F
InChI
1S/C6H5F2NO2S/c7-4-2-1-3-5(8)6(4)12(9,10)11/h1-3H,(H2,9,10,11)
InChI key
RVVVGGCOFWWDEL-UHFFFAOYSA-N
General description
2,6-Difluorobenzenesulfonamide is a fluorinated benzenesulfonamide that can be prepared by reacting 2,6-difluorobenzenesulfonyl chloride with 29% ammonium hydroxide. It forms complexes with human carbonic anhydrase II (HCA). X-ray crystal structure of these complexes have been studied.
Application
2,6-Difluorobenzenesulfonamide can be prepared from N-(4-chlorophenyl)-N′-[(2,6-di fluorophenyl)-sulfonyl]urea.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Journal of Agricultural and Food Chemistry, 24(5), 1065-1068 (1976)
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Chemistry, an Asian journal, 2(1), 94-105 (2007-04-19)
This paper describes a calorimetric study of the association of a series of seven fluorinated benzenesulfonamide ligands (C6H(n)F(5-n)SO2NH2) with bovine carbonic anhydrase II (BCA). Quantitative structure-activity relationships between the free energy, enthalpy, and entropy of binding and pKa and log
Drug metabolism and disposition: the biological fate of chemicals, 42(8), 1292-1300 (2014-05-31)
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