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539147

Sigma-Aldrich

Ethyl chlorofluoroacetate

98%

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About This Item

Linear Formula:
Cl(F)CHCO2C2H5
CAS Number:
401-56-9
Molecular Weight:
140.54
EC Number:
206-930-5
MDL number:
MFCD00039333
UNSPSC Code:
12352100
PubChem Substance ID:
24878381
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

100

Assay

98%

refractive index

n20/D 1.396 (lit.)

bp

133 °C (lit.)

density

1.212 g/mL at 25 °C (lit.)

functional group

chloro
ester
fluoro

SMILES string

CCOC(=O)C(F)Cl

InChI

1S/C4H6ClFO2/c1-2-8-4(7)3(5)6/h3H,2H2,1H3

InChI key

WUHVJSONZHSDFC-UHFFFAOYSA-N

Related Categories

Application

Ethyl chlorofluoroacetate may be used in the synthesis of:
  • chlorofluoroacetamide[1]
  • ethyl α-fluoro silyl enol ether[2]
  • chlorofluoroacetyl chloride[3]

Pictograms

FlameCorrosion
GHS02,GHS05

Signal Word

Danger

Hazard Statements

H226,H314

Hazard Classifications

Flam. Liq. 3 - Skin Corr. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

125.0 °F - closed cup

Flash Point(C)

51.67 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCP0380
MKCD0678
MKBP6299V
MKBB4044
MKAA2927

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Xiao-Ting Huang et al.
The Journal of organic chemistry, 67(10), 3231-3234 (2002-05-11)
Ethyl alpha-fluoro silyl enol ether is stereoselectively synthesized in high yield from inexpensive chlorofluoroacetate and Mg (or Zn) in DMF (or HMPA). Lewis acid promoted aldol reaction of this enol ether with aldehydes and ketones gives alpha-fluoro-beta-hydroxy esters in good
One-step method for converting esters to acyl chlorides.
Middleton WJ.
The Journal of Organic Chemistry, 44(13), 2291-2292 (1979)
The preparation of some derivatives of chlorofluoroacetic acid.
Young JA and Tarrant P.
Journal of the American Chemical Society, 71(1), 3278-3285 (1949)

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