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299154

Sigma-Aldrich

L-Methionine-(methyl-13C,d3)

≥99 atom % 13C, ≥99 atom % D, ≥99% (CP)

Synonym(s):

SILAC Amino Acid

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About This Item

Linear Formula:
13CD3SCH2CH2CH(NH2)CO2H
CAS Number:
73488-65-0
Molecular Weight:
153.22
MDL number:
MFCD00002624
UNSPSC Code:
12352209
PubChem Substance ID:
24858018
NACRES:
NA.12

isotopic purity

≥99 atom % 13C
≥99 atom % D

Assay

≥99% (CP)

form

powder

optical activity

[α]25/D +23.1°, c = 1 in 1 M HCl

technique(s)

protein expression: suitable

mp

284 °C (dec.) (lit.)

mass shift

M+4

SMILES string

[2H][13C]([2H])([2H])SCC[C@H](N)C(O)=O

InChI

1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1/i1+1D3

InChI key

FFEARJCKVFRZRR-ZIHWZSJBSA-N

Application

Used in the methodology of stable isotope tagging of epitopes (SITE) for identification of virus-induced peptides in vaccine development.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Martin Bachman et al.
Nature chemical biology, 11(8), 555-557 (2015-06-23)
5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable
Hugo D Meiring et al.
Molecular & cellular proteomics : MCP, 5(5), 902-913 (2006-01-25)
Identification of peptides presented in major histocompatibility complex (MHC) class I molecules after viral infection is of strategic importance for vaccine development. Until recently, mass spectrometric identification of virus-induced peptides was based on comparative analysis of peptide pools isolated from
Daniele Musiani et al.
Science signaling, 12(575) (2019-04-04)
Protein arginine methyltransferases (PRMTs) catalyze arginine methylation on both chromatin-bound and cytoplasmic proteins. Accumulating evidence supports the involvement of PRMT5, the major type II PRMT, in cell survival and differentiation pathways that are important during development and in tumorigenesis. PRMT5
Valeria Spadotto et al.
Nucleic acids research, 48(1), 96-115 (2019-11-30)
MicroRNA (miRNA) biogenesis is a tightly controlled multi-step process operated in the nucleus by the activity of the Microprocessor and its associated proteins. Through high resolution mass spectrometry (MS)- proteomics we discovered that this complex is extensively methylated, with 84
Daniele Musiani et al.
Cell reports, 30(4), 1208-1222 (2020-01-30)
Protein arginine methyltransferase 1 (PRMT1) is overexpressed in various human cancers and linked to poor response to chemotherapy. Various PRMT1 inhibitors are currently under development; yet, we do not fully understand the mechanisms underpinning PRMT1 involvement in tumorigenesis and chemoresistance.
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