This product has not been tested for solubility in water. Various sources suggest that this material is poorly soluble in water at 0.5 mg/mL. The solubility reportedly increases to 3 mg/mL in PBS at pH 7.2.
238813
(±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid
97%
Synonym(s):
Trolox
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About This Item
Empirical Formula (Hill Notation):
C14H18O4
CAS Number:
Molecular Weight:
250.29
Beilstein:
1384051
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay:
97%
Pricing and availability is not currently available.
Recommended Products
Quality Level
Assay
97%
storage condition
under inert gas
mp
187-189 °C (lit.)
functional group
carboxylic acid
storage temp.
2-8°C
SMILES string
Cc1c(C)c2OC(C)(CCc2c(C)c1O)C(O)=O
InChI
1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)
InChI key
GLEVLJDDWXEYCO-UHFFFAOYSA-N
Gene Information
rat ... Akr1b1(24192)
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General description
Application
(±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox) has been used in 6-hydroxy-2,5,7,8-tetramethyl chromane-2-carboxylic acid equivalent antioxidant assay (TEAC) to determine the total antioxidant capacity of different fruit species[5].
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Legal Information
related product
Product No.
Description
Pricing
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Customers Also Viewed
C Giulivi et al.
Archives of biochemistry and biophysics, 303(1), 152-158 (1993-05-15)
The reactivity of Trolox C, a water-soluble analog of vitamin E, toward protein radicals formed during the oxidation of metmyoglobin and the therefrom derived molecular products was examined in terms of the ability of the phenolic antioxidant to prevent specific
Gláucia E M L Siervo et al.
Biology of reproduction, 100(1), 112-122 (2018-07-17)
Spermatogenesis and steroidogenesis are not fully established during puberty. Especially during this period, children and adolescents may be chronically sleep deprived due to early school hours and constant exposure to artificial light and interactive activities. We have previously shown that
R Lakshmi Sundaram et al.
Journal of ethnopharmacology, 241, 111962-111962 (2019-05-24)
Spermacoce hispida (S.hispida), a potential medicinal plant has been traditionally used as an antibacterial, antieczemic, antihypertensive, antidiabetic and antihyperlipidemic agent. Although, this plant has been claimed to protect against oxidative injury and inflammatory conditions in recent studies, its cardioprotective effect
Miguel Á Sánchez-Madrigal et al.
Foods (Basel, Switzerland), 8(7) (2019-07-25)
Effects of agave fructans as carrier agents on the encapsulation of blue corn anthocyanins using spray-drying were evaluated. Blue corn extract was mixed with 6%, 8%, 10%, and 12% (w/v) of agave fructans in duplicate and dried at 150 °C.
Jessica Scalzo et al.
Nutrition (Burbank, Los Angeles County, Calif.), 21(2), 207-213 (2005-02-23)
We wanted to determine the total antioxidant capacity (6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid equivalent antioxidant assay; TEAC) of different species and cultivars (strawberry and apple) and to characterize the TEAC among fruits of the same varieties (peach and apricot) but grafted on different
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Bonjour, est-ce que le trolox est soluble dans l'eau svp?
1 answer-
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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What is the stability of Trolox in solution? And at what temperature?
1 answer-
Unfortunately, the solution stability is not determined for this product.
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What is the molar absorption coefficient of Trolox ?
1 answer-
The molar absorption coefficient is not determined for this product.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How does the storage temperature relate to shipping conditions?
1 answer-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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What is the solubility of Product 238813, (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid?
1 answer-
Product 238813, (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid, has been reported to be soluble in DMSO, ethanol and dimethyl formamide. The solubility in these solvents is ~20mg/ml.
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