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Key Documents

SML3715

Sigma-Aldrich

SSK1

≥98% (HPLC)

Synonym(s):

(2R,3S,4S,5R,6S)-2-(acetoxymethyl)-6-(4-((((1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)oxy)methyl)-2-nitrophenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate

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About This Item

Empirical Formula (Hill Notation):
C31H34F2N4O18
CAS Number:
Molecular Weight:
788.61
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.21

Pricing and availability is not currently available.

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

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This Item
S65011A008401458031
SSK1 ≥98% (HPLC)

SML3715

SSK1

form

powder

form

powder

form

-

form

-

Quality Level

100

Quality Level

200

Quality Level

-

Quality Level

-

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

solubility

-

color

white to beige

color

white to off-white

color

-

color

-

Biochem/physiol Actions

SSK1 is a senescence cells specific killing agent that is activated by lysosomal β-galactosidase. SSK1 induces apoptosis in senescence cells through activation of p38 MAPK. Also, it induces mitochondrial DNA damage in senescent cells. In aged mice, SSK1 removes senescence cells in different tissues, attenuated low-grade inflammation and improved physical function.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    [Results of calf cartilage grafted in the human body].
    S Y Wang
    Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 23(5), 282-283 (1988-09-01)

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