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Key Documents

SAB4503894

Sigma-Aldrich

Anti-phospho-Arrestin 1 (pSer412) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 47 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P49407

UniProt accession no.

P49407

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer412)

Gene Information

human ... ARRB1(408)

General description

Arrestin 1 (ARRB1) is also termed as β-arrestin-1. This is a cytoplasmic adaptor protein located on human chromosome 11q13.

Immunogen

The antiserum was produced against synthesized peptide derived from human Arrestin 1 around the phosphorylation site of Ser412.

Immunogen Range: 369-418

Biochem/physiol Actions

Arrestin 1 (ARRB1) participates in DNA damage accumulation and cell apoptosis. Deletion of ARRB1 blocks DDR (DNA damage response) pathway activation. During hypoxia, ARRB1 controls breast cancer cell survival with the help of HIF-1 transcription factor. This gene can act as a scaffold and an adaptor in receptor endocytosis and signal transduction.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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?-arrestin1 over-expression is associated with an unfavorable prognosis in lung adenocarcinomas and correlated with vascular endothelial growth factor
Qiu C, et al.
International Journal of Clinical and Experimental Pathology, 8(4), 3785-3793 (2015)
ARRB1/?-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia
Wang P, et al.
Autophagy, 10(9), 1535-1548 (2014)
Assignment of the beta-arrestin 1 gene (ARRB1) to human chromosome 11q13
Calabrese G, et al.
Genomics, 24(1), 169-171 (1994)
ARRB1 enhances the chemosensitivity of lung cancer through the mediation of DNA damage response
Shen H, et al.
Oncology Reports, 37(2), 761-767 (2017)

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