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G9020

Sigma-Aldrich

Gastrin I human

≥95% (HPLC), powder

Synonym(s):

Gastrin I, heptadecapeptide, HG-17, Little gastrin I, human, [18-Pyroglutamic acid]big gastrin I-(18-34)-peptide amide, human, [pGlu18]-Big gastrin I fragment 18-34 amide

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About This Item

Empirical Formula (Hill Notation):
C97H124N20O31S
CAS Number:
Molecular Weight:
2098.20
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32

biological source

human

Quality Level

Assay

≥95% (HPLC)

form

powder

mol wt

2098.20

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

concentration

≤100%

technique(s)

protein expression: suitable

solubility

water: 1.00-1.04 mg/mL, clear, colorless

UniProt accession no.

storage temp.

−20°C

SMILES string

CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@@H]6CCCN6C(=O)CNC(=O)[C@@H]7CCC(=O)N7)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc8ccccc8)C(N)=O

InChI

1S/C97H124N20O31S/c1-49(2)39-68(114-95(146)71(43-54-46-100-59-18-11-9-16-57(54)59)116-97(148)73-19-12-37-117(73)76(121)48-102-85(136)60-24-30-74(119)104-60)93(144)110-65(29-35-81(130)131)91(142)109-64(28-34-80(128)129)90(141)108-63(27-33-79(126)127)89(140)107-62(26-32-78(124)125)88(139)106-61(25-31-77(122)123)87(138)103-50(3)84(135)113-69(41-52-20-22-55(118)23-21-52)86(137)101-47-75(120)105-70(42-53-45-99-58-17-10-8-15-56(53)58)94(145)111-66(36-38-149-4)92(143)115-72(44-82(132)133)96(147)112-67(83(98)134)40-51-13-6-5-7-14-51/h5-11,13-18,20-23,45-46,49-50,60-73,99-100,118H,12,19,24-44,47-48H2,1-4H3,(H2,98,134)(H,101,137)(H,102,136)(H,103,138)(H,104,119)(H,105,120)(H,106,139)(H,107,140)(H,108,141)(H,109,142)(H,110,144)(H,111,145)(H,112,147)(H,113,135)(H,114,146)(H,115,143)(H,116,148)(H,122,123)(H,124,125)(H,126,127)(H,128,129)(H,130,131)(H,132,133)/t50-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-/m0/s1

InChI key

GKDWRERMBNGKCZ-RNXBIMIWSA-N

Gene Information

human ... GAST(2520)

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Amino Acid Sequence

Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2

General description

Research area: Cell Signaling

The GAST gene is mapped to human chromosome 17q21. Gastrin is a linear peptide. It is a gastrointestinal hormone, produced by G cells in the stomach.

Application

Gastrin I human has been used:
  • to treat AGS stably transfected with gastrin receptor/cholecystokinin receptor 2 (CCK2R) (AGS-GR) cells to study the expression and secretion of clusterin (CLU) in human gastric cancer cells
  • as a component of growth medium for culturing mouse normal esophageal epithelial organoid (mNEEO)
  • as a supplement in basal culture media to use for organoid-like cultures
  • as a molecular weight marker to calibrate superdex® 30 columns.

Biochem/physiol Actions

Gastrin plays a major role in parietal cell function, gastric epithelial cell multiplication, and differentiation. It acts as a modulator in maintaining and organizing gastric mucosa. It is produced in the stomach and stimulates gastric acid secretion. Gastrin is an important growth factor for the gastrointestinal tract. Gastrin binds with high affinity to the cholecystokinin B receptor (CCKBR) that belongs to the family of G-protein coupled receptors. It induces islet differentiation in the pancreas.

Other Notes

Lyophilized from 0.1% TFA in H2O

Legal Information

Superdex is a registered trademark of Cytiva

antibody

related product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A network map of the gastrin signaling pathway.
Yashwanth Subbannayya et al.
Journal of cell communication and signaling, 8(2), 165-170 (2014-03-04)
Physiology of cholangiocytes
Physiology of the Gastrointestinal Tract (2012)
C Saillan-Barreau et al.
Diabetes, 48(10), 2015-2021 (1999-10-08)
Gastrin (G) and cholecystokinin (CCK) are gastrointestinal neuropeptides that are released into circulation during a meal. G is also transiently expressed during embryogenic and early ontogenic development of the pancreas and is believed to act on islet-cell development. Both peptides
M Y Chowers et al.
Gastroenterology, 117(5), 1113-1118 (1999-10-27)
Helicobacter pylori resides within the gastric mucosa, a niche hostile to other microorganisms. Human gastrin levels are elevated after infection and return to normal after eradication. The aim of this study was to test the direct effect of gastrin on
Steven A Saenz et al.
PloS one, 16(11), e0248034-e0248034 (2021-11-10)
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expressed in multiple immune cell populations

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