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H1400000

Hydrocortisone acetate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Hydrocortisone 21-acetate, 11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-acetate, 17-α-Hydroxycorticosterone acetate, 17-Hydroxycorticosterone 21-acetate, 21-Acetoxy-4-pregnene-11β,17α-diol-3,20-dione, 4-Pregnene-11β,17α,21-triol-3,20-dione 21-acetate

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About This Item

Empirical Formula (Hill Notation):
C23H32O6
CAS Number:
Molecular Weight:
404.50
Beilstein:
2066841
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

hydrocortisone

manufacturer/tradename

EDQM

mp

223 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChI key

ALEXXDVDDISNDU-JZYPGELDSA-N

Gene Information

human ... NR3C1(2908)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydrocortisone acetate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Repr. 1B - STOT RE 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Biljana Jancic-Stojanović et al.
Journal of AOAC International, 93(1), 102-107 (2010-03-26)
An RP-HPLC method has been optimized and validated for the simultaneous determination of hydrocortisone acetate and of lidocaine in suppositories. For the method optimization, response surface methodology was applied, and the obtained model was tested using analysis of variance. The
Jaleh Varshosaz et al.
International journal of colorectal disease, 25(10), 1159-1165 (2010-07-30)
Anti-inflammatory drugs with high potency and low systemic adverse effects, such as budesonide, are drugs of choice for the treatment of ulcerative colitis (UC). Budesonide controlled-release formulations are now being used to induce and maintain clinical remission of Crohn's disease.
Nunzia Falco et al.
International journal of pharmaceutics, 441(1-2), 589-597 (2012-11-06)
The objective of the present study was to develop an anti-inflammatory prolonged action formulation for local injection in prefilled syringes. Hydrocortisone acetate (HA) was selected as a model corticosteroid drug to be incorporated in poly(lactic-co-glycolic) (PLGA) microspheres. The formulation was
B Ramírez Andrade et al.
Journal of dairy science, 91(6), 2299-2306 (2008-05-20)
Lactation artificially induced (ART) by steroid hormones and natural lactation (NAT) after lambing were compared in 2 dairy sheep breeds (Manchega and Lacaune) in 2 experiments conducted during winter and spring. In experiment 1, ART ewes (14 Manchega and 9
Alexander Reznikov et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 60(6), 489-497 (2008-08-12)
We investigated the effects of hydrocortisone acetate administered to pregnant rats over the last gestational week on some neuroendocrine characteristics in adult female and male offspring. Prenatal glucocorticoid eliminated sex dimorphism of the neurons nuclei volumes in the medial preoptic

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