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Supelco

N-Nitrosoanatabine

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C10H11N3O
CAS Number:
Molecular Weight:
189.21
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

Assay

≥97.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable
solid phase extraction (SPE): suitable

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

storage temp.

2-8°C

SMILES string

O=NN1CC=CCC1c2cccnc2

InChI

1S/C10H11N3O/c14-12-13-7-2-1-5-10(13)9-4-3-6-11-8-9/h1-4,6,8,10H,5,7H2

InChI key

ZJOFAFWTOKDIFH-UHFFFAOYSA-N

General description

Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706031. N-Nitrosoanatabine (NAT), classified in the third group of carcinogens, belongs to the class of tobacco-specific nitrosamines (TSNAs). TSNAs are carcinogenic compounds, formed through the burning, curing and fermentation of tobacco leaves. Their levels in tobacco can vary and significantly correlate to the amount of nitrate in tobacco. NAT is produced together with N′-nitrosonornicotine [NNN] and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone [NNK]) in tobacco. It can be detected in E-cigarette cartridges, mainstream tobacco smoke, snuff, etc.

Application

N-Nitrosoanatabine has been used as an analytical reference standard for the quantification of the analyte in urine samples using SupelMIP solid phase extraction (SPE) followed by liquid chromatography coupled to mass spectrometry (LC-MS). It may also be used as an analytical reference standard for the quantification of the analyte in human urine samples, replacement liquids of electronic cigarettes, snuff samples using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Analytical method for measurement of tobacco-specific nitrosamines in E-cigarette liquid and aerosol
Lee S-Y, et al.
Applied Sciences, 8(12), 2699-2699 (2018)
N-Nitroso compounds in cigarette tobacco and their occurrence in mainstream tobacco smoke
Tricker RA, et al.
Carcinogenesis, 12(2), 257-261 (1991)
Adrian A Franke et al.
Drug testing and analysis, 8(10), 1095-1099 (2015-12-02)
Approximately 600 million people worldwide practise the carcinogenic habit of betel nut/quid chewing. Carcinogenic N-nitroso compounds have been identified in saliva or urine of betel chewers and the betel alkaloid arecoline in hair from habitual betel quid chewers. However, the
Tobacco Control, An Issue of Nursing Clinics-E-Book, 47(1) (2012)
Determination of tobacco-specific nitrosamines in replacement liquids of electronic cigarettes by liquid chromatography?tandem mass spectrometry
Kim J-H and Shin S-H
Journal of Chromatography A, 1291, 48-55 (2013)

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