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Key Documents

MAB1307

Sigma-Aldrich

Mouse Anti-Human IgG1 Antibody, clone HP6001, Fc

clone HP6001, Chemicon®, from mouse

Synonym(s):

Anti-CD32, Anti-FCG2, Anti-FCGR2, Anti-FCGR2C, Anti-FcGRIIB, Anti-FcRII-c, Anti-FcgammaRIIb, Anti-IGFR2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.46

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

secondary antibodies

clone

HP6001, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
radioimmunoassay: suitable
western blot: suitable

isotype

IgG2b

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... FCGR2B(2213)

Specificity

Human IgG1 Fc. ELISA Specificity: (Hamilton et al., 1987) human IgG subclass 1- 100% human IgG subclass 2- 0.25% human IgG subclass 3- 0.01%

human IgG subclass 4-0.01% Isoelectric Focusing: mean pI 8.0

Immunogen

Epitope: Fc fragment

Application

Detect Human IgG1 using this Mouse anti-Human IgG1 Antibody, clone HP6001, Fc validated for use in ELISA, RIA & WB.
Research Category
Secondary & Control Antibodies
Research Sub Category
Fragment Specific Secondary Antibodies
This antibody employed as both a capture antibody and a detection antibody for human IgG1 in enzyme linked immunosorbent assays, radio-immunoassay and EIA affinity immunoblots (Papadea et al., 1985; Hamilton, et al., 1987).

Optimal working dilutions must be determined by end user.

Linkage

Replaces: MABN1055

Physical form

Format: Purified
Purified immunoglobulin. Liquid in 0.02 M Phosphate buffer, 0.25 M NaCl containing 0.1% sodium azide.

Storage and Stability

Maintain at 2-8°C in undiluted aliquots for up to 6 months.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lei Tian et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 28(1), 201-214 (2021-10-15)
mAbs blocking immune checkpoints have emerged as important cancer therapeutics, as exemplified by systemic administration of the IgG1 anti-CD47 mAb that blocks the "don't eat me" pathway. However, this strategy is associated with severe toxicity. To improve therapeutic efficacy while
Bo Xu et al.
Nature communications, 12(1), 5908-5908 (2021-10-10)
Oncolytic herpes simplex virus-1 is capable of lysing tumor cells while alerting the immune system. CD47, in collaboration with SIRPα, represents an important immune checkpoint to inhibit phagocytosis by innate immune cells. Here we show locoregional control of glioblastoma by
Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab-CCL5 fusion protein via innate and adaptive immunity.
Tian, et al.
Nature cancer, 3, 1318-1335 (2023)
Suzanne E Barbour et al.
Infection and immunity, 70(6), 2780-2786 (2002-05-16)
Several lines of evidence indicate that the monocytes of subjects with localized juvenile periodontitis (LJP) are functionally distinct from cells of age- and race-matched nonperiodontitis (NP) subjects. Among the abnormalities are the propensity to secrete large amounts of prostaglandin E(2)
R C Williams et al.
Arthritis and rheumatism, 40(1), 109-123 (1997-01-01)
To characterize immunologic specificity and possible antiidiotype activity of IgG anti-F(ab')2 in normal subjects as well as in patients with active and inactive systemic lupus erythematosus (SLE). IgG anti-F(ab')2 and anti-double-stranded DNA (anti-dsDNA) were affinity isolated from immunoadsorption columns of

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