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Key Documents

ABN471

Sigma-Aldrich

Anti-TMEM18 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Transmembrane protein 18, TMEM18

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, mouse

species reactivity (predicted by homology)

human (immunogen homology)

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... TMEM18(129787)

General description

Transmembrane protein 18 (TMEM18) is a transcription repressor and cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC). Recent studies have shown that overexpression of TMEM18 provides NSCs and neural precursors an increased migration capacity towards glioblastoma cells, while functional inactivation of the gene resulted in an almost complete loss of migration activity. This evidence implies that TMEM18 could be a potential target in NSC-based glioma therapy. Other studies suggest that TMEM18 loci is associated with higher than normal body mass index (BMI) and obesity, and may play a CNS-related role in predisposition to obesity.

Immunogen

KLH-conjugated linear peptide corresponding to human TMEM18.

Application

Anti-TMEM18 Antibody is a highly specific rabbit polyclonal antibody, that targets TMEM18 & has been tested in western blotting, IHC & Immunofluorescence.
Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected TMEM18 in mouse brain tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected TMEM18 in mouse brain tissue.
Research Category
Neuroscience
Research Sub Category
Sensory & PNS

Quality

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected TMEM18 in 15 µg of rat brain tissue lysate.

Target description

~27 kDa observed. Uniprot describes 2 isoforms at ~15 kDa and ~16 kDa

Physical form

Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Rat brain tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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