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850182P

Avanti

08:0 PI(4)P

Avanti Research™ - A Croda Brand

Synonym(s):

PIP[4′](8:0/8:0)

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About This Item

Empirical Formula (Hill Notation):
C25H54N2O16P2
CAS Number:
1246303-11-6
Molecular Weight:
700.65
UNSPSC Code:
51191904
NACRES:
NA.25

description

1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′-phosphate) (ammonium salt)

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (with stopper and crimp cap (850182P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850182P-500ug))

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+]

General description

08:0 PIP is a phosphoinositol phosphate (PIP). Among prokaryotes, PI is synthesized by mycobacteria and few other bacterial genera.
Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.

Application

08:0 PIP has been used to prepare multilamellar vesicle liposomes (MLV) for lipid binding assays. It is also suitable for use in the formation of protein-lipid tube and to examine fluorescence spectrum for analysing the PIP/sterol exchange properties of the Osh1 OSBP-related domain (ORD)

Biochem/physiol Actions

08:0 PIP can control ion channel activity. Phosphoinositol phosphates (PIPs) with short acyl chains, that are soluble in water can be used for reversible transport into the plasma membrane.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850182P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850182P-500ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Intracellular traffic of the lysine and glutamic acid rich protein KERP1 reveals features of endomembrane organization in Entamoeba histolytica
Perdomo D, et al.
Cellular Microbiology, 18(8), 1134-1152 (2016)
An endophilin-dynamin complex promotes budding of clathrin-coated vesicles during synaptic vesicle recycling
Sundborger A, et al.
Journal of Cell Science, 124(1), 133-143 (2011)
Short-chain phosphoinositide partitioning into plasma membrane models
Collins MD and Gordon SE
Biophysical Journal, 105(11), 2485-2494 (2013)
Structural basis for phosphatidylinositol-phosphate biosynthesis
Clarke OB, et al.
Nature Communications, 6, 8505-8505 (2015)
Ke Wang et al.
The Journal of biological chemistry, 287(45), 37964-37972 (2012-09-15)
Macroautophagy (hereafter autophagy) is a degradative cellular pathway that protects eukaryotic cells from stress, starvation, and microbial infection. This process must be tightly controlled because too little or too much autophagy can be deleterious to cellular physiology. The phosphatidylinositol (PtdIns)
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