Skip to Content
Merck
  • Titanium dioxide nanotube modified implants: an animal study on bone formation.

Titanium dioxide nanotube modified implants: an animal study on bone formation.

Journal of nanoscience and nanotechnology (2013-07-19)
Kwi-Dug Yun, Sang-Won Park, Kwang-Min Lee, Hyun-Seung Kim, Mong-Sook Vang, Hong-So Yang, Jeong-Tae Koh, Seong-Soo Kang, Gye-Jeong Oh, Ga-Hyun Kim, Min-Kyung Ji, Gab-Woon Hwang, Hyun-Pil Lim
ABSTRACT

This study examined the bone response to titanium dioxide nanotube modified implants. A total of 24 implants were placed in the femur of 4 beagles. Before placement, screw-shaped implants were classified into 3 groups; machined surface (group M), titanium dioxide nanotube modification of the machined surface (group MN) and titanium dioxide nanotube modification of the RBM surface (group RN). The texture morphology was observed via scanning electron microscopy. Animals were euthanized after 4 and 12 weeks of submerged healing and the histologic and histomorphometric analyses were performed. Groups MN and RN showed a significantly higher percentage of mineralized bone than that in group M (p < 0.05). The results of this in vivo study constitute significant evidence that the presence of the titanium dioxide nanotubes enhance osseointegration of implants.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Titanium(IV) oxide, mixture of rutile and anatase, nanoparticles, <150 nm particle size (volume distribution, DLS), dispersion, 40 wt. % in H2O, 99.5% trace metals basis
Sigma-Aldrich
Titanium(IV) oxide, rutile, nanopowder, <100 nm particle size, 99.5% trace metals basis
Sigma-Aldrich
Titanium(IV) oxide, mixture of rutile and anatase, nanopowder, <100 nm particle size (BET), 99.5% trace metals basis
Sigma-Aldrich
Titanium(IV) oxide, rutile, <001>, (single crystal substrate), ≥99.9% trace metals basis, L × W × thickness 10 mm × 10 mm × 0.5 mm
Titanium, IRMM®, certified reference material, 0.5 mm wire
Titanium, IRMM®, certified reference material, 0.5 mm foil
Sigma-Aldrich
Titanium(IV) oxide, rutile, 99.995% trace metals basis
Sigma-Aldrich
Titanium, wire, diam. 0.81 mm, 99.7% trace metals basis
Sigma-Aldrich
Titanium, 5-10 mm, ≥99.99% trace metals basis (purity exclusive of Na and K content)
Sigma-Aldrich
Titanium, foil, thickness 0.025 mm, 99.98% trace metals basis
Sigma-Aldrich
Titanium, wire, diam. 1.0 mm, 99.99% trace metals basis
Sigma-Aldrich
Titanium, foil, thickness 2.0 mm, 99.7% trace metals basis
Sigma-Aldrich
Titanium, wire, diam. 0.25 mm, 99.7% trace metals basis
Sigma-Aldrich
Titanium(IV) oxide, rutile, ≥99.98% trace metals basis
Sigma-Aldrich
Titanium(IV) oxide, rutile, powder, <5 μm, ≥99.9% trace metals basis
Sigma-Aldrich
Titanium, foil, thickness 0.127 mm, 99.7% trace metals basis
Titanium, IRMM®, certified reference material, 0.1 mm foil
Sigma-Aldrich
Titanium, foil, thickness 0.25 mm, 99.7% trace metals basis
Sigma-Aldrich
Titanium, wire, diam. 0.5 mm, 99.99% trace metals basis
Sigma-Aldrich
Titanium, sponge, 1-20 mm, 99.5% trace metals basis
Sigma-Aldrich
Titanium, powder, −100 mesh, 99.7% trace metals basis
Sigma-Aldrich
Titanium, evaporation slug, diam. × L 6.3 mm × 6.3 mm, ≥99.99% trace metals basis
Sigma-Aldrich
Titanium, foil, thickness 0.25 mm, 99.99% trace metals basis
Sigma-Aldrich
Titanium(IV) oxide, contains 1% Mn as dopant, nanopowder, <100 nm particle size (BET), ≥97%
Sigma-Aldrich
Titanium, powder, <45 μm avg. part. size, 99.98% trace metals basis
Sigma-Aldrich
Titanium(IV) oxide, anatase, powder, 99.8% trace metals basis
Sigma-Aldrich
Titanium, foil, thickness 0.127 mm, ≥99.99% trace metals basis
Sigma-Aldrich
Titanium, foil, thickness 0.5 mm, 99.99% trace metals basis
Sigma-Aldrich
Titanium, sputtering target, diam. × thickness 2.00 in. × 0.25 in., 99.995% trace metals basis
Sigma-Aldrich
Titanium(IV) oxide, anatase, powder, −325 mesh, ≥99% trace metals basis