1005706

Glacial acetic acid

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): Acetic acid, Ethanoic acid, Methanecarboxylic acid, Glacial acetic acid
• Linear Formula: CH₃CO₂H
• CAS Number: 64-19-7
• Molecular Weight: 60.05
• Beilstein: 506007
• MDL number: MFCD00036152
• UNSPSC Code: 41116107
• PubChem Substance ID: 329748133
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• vapor density: 2.07 (vs air)
• API family: glacial acetic acid
• autoignition temp.: 800 °F
• expl. lim.: 16 %, 92 °F; 4 %, 59 °F
• manufacturer/tradename: USP
• technique(s): gas chromatography (GC): suitable
• refractive index: n20/D 1.371 (lit.)
• bp: 117-118 °C (lit.)
• mp: 16.2 °C (lit.)
• density: 1.04 g/mL at 25 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: [F2C(F2C)13F3C]C(O)=O
• InChI: 1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)
• InChI key: QTBSBXVTEAMEQO-UHFFFAOYSA-N

Description

General description

Glacial acetic acid is the trivial name used to describe pure acetic acid in an anhydrous state. It is a clear and hygroscopic weak acid, typically available in concentrations ranging from 99.5% to 100%. The name "glacial" refers to the ice-like crystals that form at a temperature slightly below room temperature (16.6°C or 61.9°F), like the German term "Eisessig" (ice-vinegar). Despite being classified as a weak acid, glacial acetic acid is a corrosive poison that can cause harm or even be fatal when in contact with human tissue. Improper storage and handling of glacial acetic acid can pose inherent risks and may lead to patient injuries if not appropriately diluted. Acetic acid/acetate is a common counter ion in peptide preparations.
Glacial acetic acid USP reference standard is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Glacial acetic acid USP reference standard for use in specified quality tests and assays. It is also used to prepare standard solution by using liquid chromatography coupled to a UV detector according to the general chapter of United States Pharmacopeia (USP). Based directly on official monographs published in the USP-NF, these highly characterized physical specimens are used in testing by pharmaceutical and related industries to help ensure the identity, strength, quality, and purity of peptide-based medicines.

Further information is available in the general chapter, 503- ACETIC ACID IN PEPTIDES, USP43-NF38 - 6741 of the USP (United States Pharmacopeia).

Other Notes

This product is part of the USP Biologics program.

Sales restrictions may apply.

Safety Information

• Pictograms: GHS02,GHS05
• Signal Word: Danger
• Hazard Statements: H226,H314
• Precautionary Statements: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 102.2 °F - closed cup
• Flash Point(C): 39 °C - closed cup