UC160

4-Hydroxytolbutamide

≥98% (HPLC)

• Synonym(s): N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide
• Empirical Formula (Hill Notation): C₁₂H₁₈N₂O₄S
• CAS Number: 5719-85-7
• Molecular Weight: 286.35
• MDL number: MFCD00144466
• UNSPSC Code: 12161501
• PubChem Substance ID: 24724642
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: solid
• color: white
• mp: 100-102 °C
• solubility: ethanol: soluble 12 mg/mL; 0.1 M NaOH: soluble 4 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: CCCCNC(=O)NS(=O)(=O)c1ccc(CO)cc1
• InChI: 1S/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16)
• InChI key: SJRHYONYKZIRPM-UHFFFAOYSA-N

Description

Application

4-Hydroxytolbutamide has been used as a standard to assay the fungal biotransformation of tolbutamide to 4′-hydroxytolbutamide.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Metabolite of tolbutamide; formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes.

Preparation Note

4-Hydroxytolbutamide is soluble in ethanol at 12 mg/mL and is also soluble in 0.1 M NaOH at 4 mg/ml. It is insoluble in water.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves