T6402

Anti-τ (Tau) antibody produced in rabbit

whole antiserum

• Synonym(s): Anti-DDPAC, Anti-FTDP-17, Anti-MAPTL, Anti-MSTD, Anti-MTBT1, Anti-MTBT2, Anti-PPND, Anti-PPP1R103, Anti-TAU, Anti-tau-40
• MDL number: MFCD00164745
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: whole antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• contains: 15 mM sodium azide
• species reactivity: chicken, rat, mouse
• technique(s): western blot: 1:100 using rat or mouse brain tissue extract
• UniProt accession no.: P19332
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MAPT(4137)

Description

General description

Tau (τ), also known as MAPT (microtubule associated protein tau) is encoded by the gene mapped on human chromosome 17q21.3. It is highly expressed in neurons but is most prominent in axons.

Tau (τ), also known as microtubule associated protein tau (MAPT) is encoded by the gene mapped on human chromosome 17q21.3. It is highly expressed in neurons but is most prominent in axons. Tau is a heat stable microtubule associated protein (MAP) with a molecular weight of 55- 65 kDa.

Specificity

The antibody shows wide species reactivity. Anti-τ does not react with MAP1, MAP2 or tubulin. the antibody reacts with τ, one of the two major classes of heat stable microtubule-associated proteins (MAPs).

Immunogen

τ proteins from chicken embryo brain microtubules.

Application

Anti-τ (Tau) antibody produced in rabbit has been used as a primary antibody in western blotting.

Biochem/physiol Actions

Removal of Tau (τ) results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). Tau helps in the assembly and maintenance of microtubule structure.

Variation in the MAPT gene encoding tau protein results in frontotemporal dementia. Tau protein acts as a substrate for many kinases.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable