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Key Documents

SAB4503369

Sigma-Aldrich

Anti-Calcium Sensing Receptor antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CASR, CaSR, Extracellular calcium-sensing receptor, PCaR1, Parathyroid Cell calcium-sensing receptor

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About This Item

MDL number:
MFCD02262635
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 120 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P41180

UniProt accession no.

P41180

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CASR(846)

General description

Anti-Calcium Sensing Receptor Antibody detects endogenous levels of total Calcium Sensing Receptor protein.
The calcium sensing receptor (CASR) is a 1078 amino acid protein. It has 11 exons and is located on human chromosome 3q13.33-q21.1. CASR belongs to the C family of G protein–coupled receptors. It is located in the parathyroid gland and the thick ascending limb of the Henle loop.

Immunogen

The antiserum was produced against synthesized peptide derived from human Calcium Sensing Receptor.

Immunogen Range: 854-903

Biochem/physiol Actions

Calcium sensing receptor (CASR) modulates the activities of cells according to the extracellular calcium concentration. It also plays a major role in controlling parathyroid hormone (PTH) secretion. CASR has a vital role in signal transduction pathways in various tissues like parathyroid gland, kidney, gastrointestinal tract, placenta, pancreas and brain. Mutation in the gene is linked with autosomal dominant hypocalcemic, hypercalciuria and Bartter syndrome.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Genetic Risk Factors for Idiopathic Urolithiasis: A Systematic Review of the Literature and Causal Network Analysis
Taguchi K, et al.
European eurology focus, 3(1), 72-81 (2017)
Calcium-Sensing Receptors
Goodman WG.
Seminars in Nephrology, 24 (2004)
Elena Dyukova et al.
Journal of cellular physiology, 232(9), 2508-2518 (2016-09-24)
Nitric oxide (NO)-deficiency as it occurs during endothelial dysfunction activates the endothelin-1 (ET-1) system and increases the expression of receptor activity modifying protein (RAMP)-1 that acts as a chaperon for calcium-sensing receptors (CaR) that have recently been identified to improve
Guoliang Zhang et al.
Aging, 11(19), 8313-8328 (2019-10-03)
In this study, we used high-throughput RNA sequencing to identify mRNAs, long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) that are differentially expressed in the Substantia Nigra (SN) of aged and young rats. Gene Ontology and Kyoto Encyclopedia of Genes

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