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PZ0156

Sigma-Aldrich

UK-383,367

≥98% (HPLC)

Synonym(s):

(βR)-3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide, 5-{(1R)-4-Cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazole-3-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C15H24N4O4
CAS Number:
348622-88-8
Molecular Weight:
324.38
MDL number:
MFCD19690945
UNSPSC Code:
41121800
PubChem Substance ID:
329823739
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D ≥15°, c = 0.5 in methanol

color

white to off-white

solubility

DMSO: >30 mg/mL

storage temp.

room temp

SMILES string

NC(=O)c1noc(n1)[C@H](CCCC2CCCCC2)CC(=O)NO

InChI

1S/C15H24N4O4/c16-13(21)14-17-15(23-19-14)11(9-12(20)18-22)8-4-7-10-5-2-1-3-6-10/h10-11,22H,1-9H2,(H2,16,21)(H,18,20)/t11-/m1/s1

InChI key

ARJCBSRIPGJMAD-LLVKDONJSA-N

Biochem/physiol Actions

UK-383,367 is a procollagen C-proteinase (PCP) inhibitor.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Yael Eshed-Eisenbach et al.
Neuron, 106(5), 806-815 (2020-03-27)
During development of the peripheral nervous system (PNS), Schwann-cell-secreted gliomedin induces the clustering of Na+ channels at the edges of each myelin segment to form nodes of Ranvier. Here we show that bone morphogenetic protein-1 (BMP1)/Tolloid (TLD)-like proteinases confine Na+

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